Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters Journal Article

   


Authors: Zhang, X. J.; Li, Z.; Han, Z.; Sultan, K. T.; Huang, K.; Shi, S. H.
Article Title: Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters
Abstract: GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances, and promotes action potential generation and synchronous firing. Interestingly, this selective electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory neurons. These results suggest a link between the lineage relationship of neocortical interneurons and their precise functional organization. © 2017 The Author(s).
Keywords: nonhuman; embryo; interneuron; nerve cell; retroviridae; synapse; perinatal period; preoptic area; synaptogenesis; action potential
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-07-13
Start Page: 16091
Language: English
DOI: 10.1038/ncomms16091
PROVIDER: scopus
PMCID: PMC5511369
PUBMED: 28703129
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023741170&doi=10.1038%2fncomms16091&partnerID=40&md5=c3dbf0041035013dbb7f92d678c03445
Notes: Article -- Export Date: 2 August 2017 -- Source: Scopus
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MSK Authors
  1. Song-Hai Shi
    52 Shi
  2. Xinjun Zhang
    13 Zhang
  3. Khadeeja T Sultan
    9 Sultan
  4. Zhizhong Li
    11 Li
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