Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex Journal Article

Authors: Sultan, K. T.; Liu, W. A.; Li, Z. L.; Shen, Z.; Li, Z.; Zhang, X. J.; Dean, O.; Ma, J.; Shi, S. H.
Article Title: Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex
Abstract: Diverse γ-aminobutyric acid (GABA)-ergic interneurons provide different modes of inhibition to support circuit operation in the neocortex. However, the cellular and molecular mechanisms underlying the systematic generation of assorted neocortical interneurons remain largely unclear. Here we show that NKX2.1-expressing radial glial progenitors (RGPs) in the mouse embryonic ventral telencephalon divide progressively to generate distinct groups of interneurons, which occupy the neocortex in a time-dependent, early inside-out and late outside-in, manner. Notably, the late-born chandelier cells, one of the morphologically and physiologically highly distinguishable GABAergic interneurons, arise reliably from continuously dividing RGPs that produce non-chandelier cells initially. Selective removal of Partition defective 3, an evolutionarily conserved cell polarity protein, impairs RGP asymmetric cell division, resulting in premature depletion of RGPs towards the late embryonic stages and a consequent loss of chandelier cells. These results suggest that consecutive asymmetric divisions of multipotent RGPs generate diverse neocortical interneurons in a progressive manner. © 2018, The Author(s).
Keywords: controlled study; protein expression; unclassified drug; nonhuman; animal cell; mouse; animal tissue; apoptosis; embryo; cell protein; animal experiment; protein; transcription factor; neural stem cell; cell differentiation; morphology; physiology; gabaergic system; interneuron; molecular analysis; cell migration; glia cell; cell polarity; neocortex; multipotent stem cell; cre recombinase; nervous system development; somatostatin; corpus striatum; primary somatosensory cortex; hippocampus; inhibition; telencephalon; transcription factor nkx2.1; parvalbumin; chemical compound; asymmetric cell division; cell component; male; female; article; radial glial progenitor; partition defective 3
Journal Title: Nature Communications
Volume: 9
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2018-11-02
Start Page: 4595
Language: English
DOI: 10.1038/s41467-018-07055-7
PUBMED: 30389944
PROVIDER: scopus
PMCID: PMC6214958
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Song-Hai Shi
    43 Shi
  2. Xinjun Zhang
    11 Zhang
  3. Khadeeja T Sultan
    9 Sultan
  4. Zhizhong Li
    9 Li
  5. Wenying   Liu
    3 Liu