Don't go chasing waterfalls: Excessive fluid resuscitation in severe sepsis and septic shock Journal Article
| Author: | Chen, L. |
| Article Title: | Don't go chasing waterfalls: Excessive fluid resuscitation in severe sepsis and septic shock |
| Abstract: | Aggressive fluid resuscitation is the mainstay therapy in modern sepsis management. Its efficacy was demonstrated in the landmark study by Emmanuel Rivers in 2001. However, more recent evidence largely shows that a positive fluid balance increases mortality in critically ill patients with sepsis. This article examines the theoretical benefits of fluid resuscitation and physiological responses to it that may negatively affect patients' outcome. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | outcome assessment; physiology; endothelium cell; albumin; disease severity; ringer lactate solution; sepsis; hypoxemia; sodium chloride; hemodynamics; infusion fluid; crystalloid; septic shock; lung edema; capillary leak syndrome; critically ill; glycocalyx; fluid resuscitation; hyperchloremic acidosis; human; article; excessive fluid resuscitation; vasoplegia |
| Journal Title: | Critical Care Nursing Quarterly |
| Volume: | 39 |
| Issue: | 1 |
| ISSN: | 0887-9303 |
| Publisher: | Wolters Kluwer Health | Lippincott Williams & Wilkins |
| Date Published: | 2016-01-01 |
| Start Page: | 34 |
| End Page: | 37 |
| Language: | English |
| DOI: | 10.1097/cnq.0000000000000094 |
| PROVIDER: | scopus |
| PUBMED: | 26633156 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
