Emerging strategies for cancer immunoprevention Journal Article
| Authors: | Roeser, J. C.; Leach, S. D.; McAllister, F. |
| Article Title: | Emerging strategies for cancer immunoprevention |
| Abstract: | The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some special circumstances such as in chronic inflammation, the immune system can actually contribute to the formation and progression of tumors. In recent years, there has been an explosion of novel targeted immunotherapies for advanced cancers. In the present manuscript, we explore known and potential various types of cancer prevention strategies and focus on nonvaccine-based cancer preventive strategies targeting the immune system at the early stages of tumorigenesis. © 2015 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | review; cancer risk; alpha interferon; cancer incidence; neoplasm; cd8 antigen; cd8+ t lymphocyte; cancer immunotherapy; cancer prevention; immune system; interleukin 8; regulatory t lymphocyte; cancer vaccine; cd4+ t lymphocyte; interleukin 6; interleukin 17; cd4 antigen; cytotoxic t lymphocyte antigen 4; macrophage; immunosurveillance; natural killer t cell; interleukin 1; programmed death 1 ligand 1; lymphoid cell; mast cell; human; priority journal |
| Journal Title: | Oncogene |
| Volume: | 34 |
| Issue: | 50 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-12-10 |
| Start Page: | 6029 |
| End Page: | 6039 |
| Language: | English |
| DOI: | 10.1038/onc.2015.98 |
| PROVIDER: | scopus |
| PUBMED: | 26364615 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 7 January 2016 -- 6029 -- Source: Scopus |
