Personalized oncology meets immunology: The path toward precision immunotherapy Journal Article
| Authors: | Mandal, R.; Chan, T. A. |
| Article Title: | Personalized oncology meets immunology: The path toward precision immunotherapy |
| Abstract: | Personalized oncology aims to tailor therapy by targeting the unique genetic characteristics of a patient’s tumor, whereas cancer immunotherapy focuses on activating the patient’s immune system to control the tumor. The fusion of these ostensibly separate strategies has created a new dimension for personalized cancer immunotherapy. This entails the development of next-generation cancer vaccines that target neoantigens as well as the use of mutational signatures as predictive biomarkers for clinical response. The optimal use of immunotherapeutic agents will hinge on a robust understanding of the mutational profile of a cancer’s genome that significantly dictates antitumor immunity and immunotherapeutic response. Significance: Cancer immunotherapy has provided substantial clinical benefit in a significant number of patients with advanced disease. However, the need for more precise immunotherapies and predictive biomarkers remains pressing. Recent progress in these areas has been promising and has created a framework for precision immune-oncology. © 2016 American Association for Cancer Research. All rights reserved. |
| Journal Title: | Cancer Discovery |
| Volume: | 6 |
| Issue: | 7 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2016-07-01 |
| Start Page: | 703 |
| End Page: | 713 |
| Language: | English |
| DOI: | 10.1158/2159-8290.cd-16-0146 |
| PROVIDER: | scopus |
| PMCID: | PMC4930745 |
| PUBMED: | 27107038 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2016 -- Source: Scopus |
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