Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion Journal Article
| Authors: | Schreiber, R. D.; Old, L. J.; Smyth, M. J. |
| Article Title: | Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion |
| Abstract: | Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are more fit to survive in an immunocompetent host or by establishing conditions within the tumor microenvironment that facilitate tumor outgrowth. Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles. |
| Keywords: | signal transduction; cancer survival; review; cancer growth; nonhuman; alpha interferon; rituximab; neoplasms; cd8+ t lymphocyte; t lymphocyte; lymphocytes, tumor-infiltrating; cytology; animals; mice; stat1 protein; cancer immunotherapy; immune system; interleukin 1beta; inflammation; cytogenetics; tumor antigen; carcinogenesis; cancer inhibition; immune tolerance; immune response; immunotherapy; antigens, neoplasm; gamma interferon; immunogenicity; cancer cell; cd4+ t lymphocyte; tumor immunity; immunity, innate; tumor promotion; immunity; tumor; immune deficiency; immunocompromised host; rag2 protein; trastuzumab; adaptive immunity; immunosurveillance; conceptual framework; beta interferon; myeloid differentiation factor 88; interleukin 12; immunocompetence; tumor microenvironment; interleukin 23; models, immunological; immunologic surveillance; tumor escape |
| Journal Title: | Science |
| Volume: | 331 |
| Issue: | 6024 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2011-03-25 |
| Start Page: | 1565 |
| End Page: | 1570 |
| Language: | English |
| DOI: | 10.1126/science.1203486 |
| PUBMED: | 21436444 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: SCIEA" - "Source: Scopus" |
