Bioartificial organ support for hepatic, renal, and hematologic failure Journal Article
| Authors: | Maguire, P. J.; Stevens, C.; Humes, H. D.; Shander, A.; Halpern, N. A.; Pastores, S. M. |
| Article Title: | Bioartificial organ support for hepatic, renal, and hematologic failure |
| Abstract: | The current strategy to the treatment of SIRS and MODS uses a multidisciplinary approach that emphasizes supportive therapy. Herein, we have presented a futuristic approach that focuses on replacing the function of failed organs using bioartificial technology (Table 1). Bioartificial organ technology may allow the intensivist to provide physiologic organ replacement either as a bridge to transplantation or as a 'time-buying' element until native organs that have become acutely dysfunctional or nonfunctional in a variety of clinical settings, can recover their function or regenerate their mass. As bioartificial organ technology matures, it is conceivable as an ultimate goal that non-immunogenic bioartificial organs would be miniaturized or redesigned and acutely placed within the intracorporeal space as replacement organs. |
| Keywords: | review; kidney failure; liver failure; device; adoptive immunotherapy; bioreactors; technology; hematologic disease; extracorporeal oxygenation; critical illness; blood substitutes; organ transplantation; artificial organ; humans; priority journal; artificial kidney; artificial liver; bioartificial organs; kidney, artificial; liver, artificial |
| Journal Title: | Critical Care Clinics |
| Volume: | 16 |
| Issue: | 4 |
| ISSN: | 0749-0704 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2000-10-01 |
| Start Page: | 681 |
| End Page: | 694 |
| Language: | English |
| PUBMED: | 11070811 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0749-0704(05)70140-8 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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