Square cell packing in the Drosophila embryo through spatiotemporally regulated EGF receptor signaling Journal Article


Authors: Tamada, M.; Zallen, J. A.
Article Title: Square cell packing in the Drosophila embryo through spatiotemporally regulated EGF receptor signaling
Abstract: Cells display dynamic and diverse morphologies during development, but the strategies by which differentiated tissues achieve precise shapes and patterns are not well understood. Here we identify a developmental program that generates a highly ordered square cell grid in the Drosophila embryo through sequential and spatially regulated cell alignment, oriented cell division, and apicobasal cell elongation. The basic leucine zipper transcriptional regulator Cnc is necessary and sufficient to produce a square cell grid in the presence of a midline signal provided by the EGF receptor ligand Spitz. Spitz orients cell divisions through a Pins/LGN-dependent spindle-positioning mechanism and controls cell shape and alignment through a transcriptional pathway that requires the Pointed ETS domain protein. These results identify a strategy for producing ordered square cell packing configurations in epithelia and reveal a molecular mechanism by which organized tissue structure is generated through spatiotemporally regulated responses to EGF receptor activation. Cells display diverse morphologies during development, but the strategies by which differentiated tissues achieve precise shapes and patterns are not well understood. Tamada and Zallen show, in the Drosophila embryo, that EGFR signaling spatially regulates square cell packing in epithelia through sequential cell alignment, oriented division, and apicobasal elongation. © 2015 Elsevier Inc.
Keywords: signal transduction; controlled study; nonhuman; protein domain; cell division; cell function; embryo; epidermal growth factor receptor; drosophila; cell polarity; cell shape; myosin ii; cell elongation; oriented cell division; planar polarity; egf receptor; intercalation; junctional remodeling; priority journal; article; spatiotemporal analysis
Journal Title: Developmental Cell
Volume: 35
Issue: 2
ISSN: 1534-5807
Publisher: Cell Press  
Date Published: 2015-10-26
Start Page: 151
End Page: 161
Language: English
DOI: 10.1016/j.devcel.2015.09.015
PROVIDER: scopus
PUBMED: 26506305
PMCID: PMC4939091
DOI/URL:
Notes: Export Date: 2 December 2015 -- Source: Scopus
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MSK Authors
  1. Jennifer A Zallen
    39 Zallen
  2. Masako Tamada
    6 Tamada