Entosis: Cell-in-cell formation that kills through entotic cell death Journal Article
| Authors: | Florey, O.; Kim, S. E.; Overholtzer, M. |
| Article Title: | Entosis: Cell-in-cell formation that kills through entotic cell death |
| Abstract: | Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer. © 2015 Bentham Science Publishers. |
| Keywords: | autophagy; phagocytosis; entosis; cannibalism; entotic cell death; engulfment; cell-in-cell; cell competition; lap |
| Journal Title: | Current Molecular Medicine |
| Volume: | 15 |
| Issue: | 9 |
| ISSN: | 1566-5240 |
| Publisher: | Bentham Science Publishers |
| Date Published: | 2015-01-01 |
| Start Page: | 861 |
| End Page: | 866 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 26511711 |
| DOI: | 10.2174/1566524015666151026100042#sthash.LMlg2tjg.Sp0scuBu.dpuf |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
