Entosis: Cell-in-cell formation that kills through entotic cell death Journal Article


Authors: Florey, O.; Kim, S. E.; Overholtzer, M.
Article Title: Entosis: Cell-in-cell formation that kills through entotic cell death
Abstract: Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer. © 2015 Bentham Science Publishers.
Keywords: autophagy; phagocytosis; entosis; cannibalism; entotic cell death; engulfment; cell-in-cell; cell competition; lap
Journal Title: Current Molecular Medicine
Volume: 15
Issue: 9
ISSN: 1566-5240
Publisher: Bentham Science Publishers  
Date Published: 2015-01-01
Start Page: 861
End Page: 866
Language: English
PROVIDER: scopus
PUBMED: 26511711
DOI: 10.2174/1566524015666151026100042#sthash.LMlg2tjg.Sp0scuBu.dpuf
DOI/URL:
Notes: Export Date: 2 December 2015 -- Source: Scopus
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  1. Sung Eun Kim
    6 Kim
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