Mechanisms and consequences of entosis Journal Article

   


Authors: Krishna, S.; Overholtzer, M.
Article Title: Mechanisms and consequences of entosis
Abstract: Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
Keywords: death; autophagy; phagocytosis; human cancers; aneuploidy; competition; host-defense; bax; entosis; dictyostelium-discoideum; bcl-2 family-members; cannibalism; entotic cell death; process; engulfment; cell-in-cell; cell competition; lap
Journal Title: Cellular and Molecular Life Sciences
Volume: 73
Issue: 11-12
ISSN: 1420-682X
Publisher: Springer  
Date Published: 2016-06-01
Start Page: 2379
End Page: 2386
Language: English
ACCESSION: WOS:000377775800020
DOI: 10.1007/s00018-016-2207-0
PROVIDER: wos
PMCID: PMC4889469
PUBMED: 27048820
Notes: Review -- Source: Wos
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Michael H Overholtzer
    81 Overholtzer
  2. Shefali Krishna
    7 Krishna
Related MSK Work