Authors: | Krishna, S.; Overholtzer, M. |
Article Title: | Mechanisms and consequences of entosis |
Abstract: | Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations. |
Keywords: | death; autophagy; phagocytosis; human cancers; aneuploidy; competition; host-defense; bax; entosis; dictyostelium-discoideum; bcl-2 family-members; cannibalism; entotic cell death; process; engulfment; cell-in-cell; cell competition; lap |
Journal Title: | Cellular and Molecular Life Sciences |
Volume: | 73 |
Issue: | 11-12 |
ISSN: | 1420-682X |
Publisher: | Springer |
Date Published: | 2016-06-01 |
Start Page: | 2379 |
End Page: | 2386 |
Language: | English |
ACCESSION: | WOS:000377775800020 |
DOI: | 10.1007/s00018-016-2207-0 |
PROVIDER: | wos |
PMCID: | PMC4889469 |
PUBMED: | 27048820 |
Notes: | Review -- Source: Wos |