Cyclo-oxygenase 2: A pharmacological target for the prevention of cancer Journal Article

  


Authors: Dannenberg, A. J.; Altorki, N. K.; Boyle, J. O.; Dang, C.; Howe, L. R.; Weksler, B. B.; Subbaramaiah, K.
Article Title: Cyclo-oxygenase 2: A pharmacological target for the prevention of cancer
Abstract: Understanding the mechanisms underlying carcinogenesis provides insights that are necessary for the development of therapeutic strategies to prevent cancer. Chemoprevention - the use of drugs or natural substances to inhibit carcinogenesis - is an important and rapidly evolving aspect of cancer research. We discuss evidence that cyclooxygenase 2 (COX 2), an inducible form of the enzyme, is a potential pharmacological target to prevent cancer. Key data implicating a causal relation between increased activity of COX 2 and carcinogenesis and possible mechanisms of action of COX 2 in this context are covered. Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway. © 2001 Elsevier Science Ltd.
Keywords: review; antineoplastic agents; antineoplastic agent; neoplasm; neoplasms; apoptosis; inflammation; membrane proteins; enzymology; pathology; neovascularization, pathologic; physiology; cancer invasion; biosynthesis; drug antagonism; cyclooxygenase 2; prostaglandin; prostaglandins; ptgs2 protein, human; membrane protein; neoplasm invasiveness; immunosuppressive treatment; neovascularization (pathology); isoenzymes; immunosuppression; isoenzyme; xenobiotic agent; xenobiotics; prostaglandin synthase; prostaglandin-endoperoxide synthases; humans; human
Journal Title: Lancet Oncology
Volume: 2
Issue: 9
ISSN: 1470-2045
Publisher: Elsevier Science, Inc.  
Date Published: 2001-09-01
Start Page: 544
End Page: 551
Language: English
DOI: 10.1016/s1470-2045(01)00488-0
PUBMED: 11905709
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0035468642&partnerID=40&md5=eb413b7aa184557cdfebfc4a5fa97352
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Jay O Boyle
    148 Boyle
  2. Chau Dang
    271 Dang
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