Cyclooxygenase-2: A novel molecular target for the prevention and treatment of head and neck cancer Journal Article
| Authors: | Lin, D. T.; Subbaramaiah, K.; Shah, J. P.; Dannenberg, A. J.; Boyle, J. O. |
| Article Title: | Cyclooxygenase-2: A novel molecular target for the prevention and treatment of head and neck cancer |
| Abstract: | Cyclooxygenase-2 (COX-2), an enzyme that catalyzes the synthesis of prostaglandins, is overexpressed in a variety of premalignant and malignant conditions, including oral leukoplakia and squamous cell carcinoma of the head and neck. Increased levels of COX-2 may contribute to carcinogenesis by modulating xenobiotic metabolism, apoptosis, immune surveillance, and angiogenesis. In experimental models, newly developed selective COX-2 inhibitors suppress the formation of tumors, including tongue cancer. These findings provided a rationale for a number of chemoprevention trials that are underway. Selective COX-2 inhibitors also suppress the growth and metastases of established tumors and enhance the anticancer activity of both radiotherapy and chemotherapy in experimental animals. In this review, evidence is presented that inhibition of COX-2 represents a promising strategy to prevent or possibly treat human head and neck cancers. © 2002 Wiley Periodicals, Inc. |
| Keywords: | cancer chemotherapy; protein expression; review; squamous cell carcinoma; carcinoma, squamous cell; pathophysiology; cancer radiotherapy; metabolism; cancer prevention; metastasis; apoptosis; inflammation; antineoplastic activity; angiogenesis; neovascularization, pathologic; physiology; carcinogenesis; cancer invasion; immunological tolerance; biosynthesis; immune tolerance; head and neck cancer; head and neck neoplasms; celecoxib; cyclooxygenase 2 inhibitor; sulfonamide; sulfonamides; cyclooxygenase 2; nonsteroid antiinflammatory agent; sulindac; prostaglandins; neoplasm metastasis; neoplasm invasiveness; upregulation; up-regulation; immunosurveillance; neovascularization (pathology); head and neck; head and neck tumor; leukoplakia; chemoprevention; xenobiotic metabolism; cyclooxygenase; xenobiotic agent; xenobiotics; prostaglandin synthase; prostaglandin-endoperoxide synthases; prostaglandin synthase inhibitor; cyclooxygenase inhibitors; humans; human; priority journal; support, u.s. gov't, p.h.s.; nimesulide; prostaglandin-endoperoxide synthase |
| Journal Title: | Head & Neck |
| Volume: | 24 |
| Issue: | 8 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2002-08-01 |
| Start Page: | 792 |
| End Page: | 799 |
| Language: | English |
| DOI: | 10.1002/hed.10108 |
| PUBMED: | 12203806 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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