Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract Conference Paper

  

Authors:	Dannenberg, A. J.; Altorki, N. K.; Boyle, J. O.; Lin, D. T.; Subbaramaiah, K.
Title:	Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract
Conference Title:	4th Strang International Cancer Prevention Conference
Abstract:	Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.
Keywords:	controlled study; clinical trial; conference paper; animals; mice; mice, knockout; cancer prevention; apoptosis; controlled clinical trial; enzyme inhibition; phase 2 clinical trial; lung neoplasms; lung cancer; drug screening assays, antitumor; xenograft model antitumor assays; enzyme activity; cell transformation, neoplastic; digestive system cancer; regulatory mechanism; drug mechanism; head and neck cancer; head and neck neoplasms; disease progression; celecoxib; cyclooxygenase 2 inhibitor; cyclooxygenase 2 inhibitors; colon cancer; cyclooxygenase 2; sulindac; anticarcinogenic agents; prostaglandins; neoplasms, experimental; phase 3 clinical trial; esophageal neoplasms; isoenzymes; precancerous conditions; cyclooxygenase-2; chemoprevention; barrett esophagus; carboxylyase; prostaglandin synthase; prostaglandin-endoperoxide synthases; nonsteroidal anti-inflammatory drugs; cyclooxygenase inhibitors; human; leukoplakia, oral; aerodigestive; enzyme inhibitor interaction; respiratory tract neoplasms
Journal Title	Annals of the New York Academy of Sciences
Volume:	952
Conference Dates:	2000 Nov 10-11
Conference Location:	New York, NY
ISBN:	0077-8923
Publisher:	John Wiley & Sons
Date Published:	2001-12-01
Start Page:	109
End Page:	115
Language:	English
PUBMED:	11795429
PROVIDER:	scopus
DOI:	10.1111/j.1749-6632.2001.tb02731.x
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0035683884&partnerID=40&md5=1a0fd9889a921c191371bc86e53bb694
Notes:	Presented at the 4th Strang International Cancer Prevention Conference - Cancer Prevention 2000: Molecular Mechanisms to Clinical Applications; 2000 Nov 10-11; New York, NY -- Export Date: 21 May 2015 -- Source: Scopus

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