Inhibition of cyclooxygenase-2 expression: An approach to preventing head and neck cancer Conference Paper
| Authors: | Mestre, J. R.; Chan, G.; Zhang, F.; Yang, E. K.; Sacks, P. G.; Boyle, J. O.; Shah, J. P.; Edelstein, D.; Subbaramaiah, K.; Dannenberg, A. J. |
| Title: | Inhibition of cyclooxygenase-2 expression: An approach to preventing head and neck cancer |
| Conference Title: | Strang International Cancer Prevention Conference |
| Abstract: | Cyclooxygenase (COX) catalyzes the formation of prostaglandins (PG) from arachidonic acid. A large body of evidence has accumulated to suggest that COX-2, the inducible form of COX, is important in carcinogenesis. In this study, we determined whether (1) COX-2 was overexpressed in squamous cell carcinoma of the head and neck (HNSCC) and whether (2) retinoids, a class of chemopreventive agents, blocked epidermal growth factor (EGF)-mediated activation of COX-2 expression. Levels of COX-2 mRNA were determined in 15 cases of HNSCC and 10 cases of normal oral mucosa, Nearly a 100-fold increase in amounts of COX-2 mRNA was detected in HNSCC, By immunoblot analysis, COX-2 protein was detected in 6 of 6 cases of HNSCC but was undetectable in normal mucosa, Because retinoids protect against oral cavity cancer, we investigated whether retinoids could suppress EGF-mediated induction of COX-2 in cultured oral squamous carcinoma cells. Treatment with EGF led to increased levels of COX-2 mRNA, COX-2 protein, and synthesis of PG, These effects were suppressed by a variety of retinoids, Based on the results of this study, it will be important to establish whether newly developed selective COX-2 inhibitors are useful in preventing or treating HNSCC, Moreover, the anticancer properties of retinoids may be due, in Dart, to inhibition of COX-2 expression. Combining a retinoid with a selective COX-2-inhibitor may be more effective than either agent alone in preventing cancer of the upper aerodigestive tract. |
| Keywords: | transcription; up-regulation; gene-expression; squamous-cell carcinoma; growth; epithelial-cells; colon-cancer; adenocarcinomas; trans-retinoic acid; 2nd primary tumors; human |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 889 |
| Conference Dates: | 1998 Nov 13-14 |
| Conference Location: | New York, NY |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Location: | New York |
| Date Published: | 1999-10-01 |
| Start Page: | 62 |
| End Page: | 71 |
| Language: | English |
| ACCESSION: | WOS:000085323100007 |
| PROVIDER: | wos |
| PUBMED: | 10668483 |
| DOI: | 10.1111/j.1749-6632.1999.tb08724.x |
| Notes: | Article in "Cancer Prevention: Novel Nutrient and Pharmaceutical Developments" (ISBN: 9781573311984) -- Proceedings Paper -- Conference on Cancer Prevention - Novel Nutrient and Pharmaceutical Developments -- NOV 13-14, 1998 -- NEW YORK, NEW YORK -- Source: Wos |
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