Cutting edge: Antigen-independent CD8 T cell proliferation Journal Article
| Authors: | Wong, P.; Pamer, E. G. |
| Article Title: | Cutting edge: Antigen-independent CD8 T cell proliferation |
| Abstract: | Recent analyses of CD8 T cell responses to Listeria monocytogenes infection demonstrate that the duration of in vivo T cell proliferation is not determined by the amount or duration of Ag presentation. However, the extent to which T lymphocytes are capable of proliferating in the absence of Ag is unknown. Herein we demonstrate that CD8 T lymphocytes undergo up to eight rounds of proliferation in the absence of Ag following transient, 2.5-h in vitro antigenic stimulation. Ag-independent expansion of CD8 T cells is driven by IL-2 and is further augmented by IL-7 or IL-15. These experiments clearly demonstrate that CD8 T cells undergo prolonged proliferation following transient Ag exposure and support the notion that in vivo CD8 T cell expansion following infection can be uncoupled from Ag presentation. |
| Keywords: | nonhuman; cd8 antigen; lymphocyte proliferation; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell division; interleukin 2; interleukin 7; cell line; in vitro study; tumor cells, cultured; mice, inbred balb c; mice, transgenic; antigen presentation; lymphocyte activation; bacterial proteins; immunostimulation; epitopes, t-lymphocyte; antigen-presenting cells; interleukin 15; listeriosis; listeria monocytogenes; cell selection; lymphocyte subpopulation; antigens, bacterial; heat-shock proteins; bacterial toxins; hemolysin proteins; h-2 antigens; priority journal; article; antigens, t-independent; listeria |
| Journal Title: | Journal of Immunology |
| Volume: | 166 |
| Issue: | 10 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2001-05-15 |
| Start Page: | 5864 |
| End Page: | 5868 |
| Language: | English |
| PUBMED: | 11342598 |
| PROVIDER: | scopus |
| DOI: | 10.4049/jimmunol.166.10.5864 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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