Rapid development of T cell memory Journal Article
| Authors: | Wong, P.; Lara-Tejero, M.; Ploss, A.; Leiner, I.; Pamer, E. G. |
| Article Title: | Rapid development of T cell memory |
| Abstract: | Prime-boost immunization is a promising strategy for inducing and amplifying pathogen- or tumor-specific memory CD8 T cell responses. Although expansion of CD8 T cell populations following the second Ag dose, is integral to the prime-boost strategy, it remains unclear when, after priming, memory T cells become competent to proliferate. In this study, we show that Ag-specific CD8 T cells with the capacity to undergo extensive expansion are already present at the peak of the primary immune response in mice. These early memory T cells represent a small fraction of the primary immune response and, at early time points, their potential to proliferate is obscured by large effector T cell populations that rapidly clear Ag upon reimmunization. With sufficient Ag boosting, however, secondary expansion of these memory cells can be induced as early as 5-7 days following primary immunization. Importantly, both early and delayed boosting result in similar levels of protective immunity to subsequent pathogen challenge. Early commitment and differentiation of memory T cells during primary immunization suggest that a short duration between priming and boosting is feasible, providing potential logistic advantages for large-scale prime-boost vaccination of human populations. |
| Keywords: | nonhuman; flow cytometry; cd8 antigen; cell proliferation; t lymphocyte; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell division; animal model; cell differentiation; cytotoxicity; mice, inbred balb c; lymphocyte differentiation; lymphocyte activation; kinetics; antigen specificity; vaccination; adoptive transfer; memory cell; t lymphocyte subpopulation; immunologic memory; spleen cell; immunization; immunization, secondary; synthetic peptide; priority journal; article |
| Journal Title: | Journal of Immunology |
| Volume: | 172 |
| Issue: | 12 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2004-06-15 |
| Start Page: | 7239 |
| End Page: | 7245 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15187098 |
| DOI: | 10.4049/jimmunol.172.12.7239 |
| DOI/URL: | |
| Notes: | J. Immunol. -- Cited By (since 1996):37 -- Export Date: 16 June 2014 -- CODEN: JOIMA C2 - 15187098 -- Source: Scopus |
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