Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen Journal Article
| Authors: | Ploss, A.; Leiner, I.; Pamer, E. G. |
| Article Title: | Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen |
| Abstract: | CD8 T cell populations restricted by H2-M3 MHC class Ib molecules expand rapidly during primary Listeria monocytogenes infection but only minimally upon reinfection. In contrast, CD8 T cells restricted by MHC class Ia molecules undergo more delayed expansion during primary infection but rapid and robust expansion following reinfection. In this study we demonstrate that primary H2-M3-restricted CD8 T cell responses are unaffected by the frequency of naive MHC class Ia-restricted T cells during L. monocytogenes infection. The magnitude of H2-M3-restricted memory responses, in contrast, is down-modulated by increasing frequencies of MHC class Ia-restricted effector T cells following secondary systemic infection. Suppression by MHC class Ia-restricted T cells, however, is not a universal feature of MHC class Ib-restricted memory responses. Primary systemic L. monocytogenes infection followed by secondary tissue infection, for example, results in robust expansion of H2-M3-restricted memory T cells in draining lymph nodes, despite the activation of MHC class Ia-restricted memory T cell responses. Thus, whereas MHC class Ia-restricted memory T cell populations predominate in spleens following systemic reinfection, H2-M3-restricted memory T cell responses remain prominent in lymph nodes draining localized infections. Our studies demonstrate that interactions between CD8 T cell populations can differ, depending on the status of the responding T cells (naive vs memory) and the route of reinfection. These results may have important implications for prime-boost vaccination strategies. Copyright © 2005 by The American Association of Immunologists, Inc. |
| Keywords: | controlled study; nonhuman; lymph nodes; cd8 antigen; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; animal tissue; spleen; mice, inbred c57bl; cell type; dendritic cells; immune response; lymph node; histocompatibility antigens class i; effector cell; cytotoxicity, immunologic; vaccine production; histocompatibility antigens class ii; memory cell; cell interaction; antigen presenting cell; immunologic memory; listeria monocytogenes; listeria infections; major histocompatibility antigen class 1; major histocompatibility complex restriction; immunization; h2 m3 restricted memory t cell; reinfection; h-2 antigens |
| Journal Title: | Journal of Immunology |
| Volume: | 175 |
| Issue: | 9 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2005-11-01 |
| Start Page: | 5998 |
| End Page: | 6005 |
| Language: | English |
| PUBMED: | 16237094 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 24 October 2012" - "CODEN: JOIMA" - "Source: Scopus" |
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