H2-M3-restricted memory T cells: Persistence and activation without expansion Journal Article
| Authors: | Kerksiek, K. M.; Ploss, A.; Leiner, I.; Busch, D. H.; Pamer, E. G. |
| Article Title: | H2-M3-restricted memory T cells: Persistence and activation without expansion |
| Abstract: | H2-M3-restricted T cells respond more rapidly to primary Listeria monocytogenes infection than conventional MHC class Ia-restricted T cells. Reinfection with L. monocytogenes, while inducing explosive proliferation of H2-Kd-restricted T cells, does not stimulate significant expansion of H2-M3-restricted CTL. These disparate responses to reinfection are apparent within 5 days of primary L. monocytogenes infection. However, H2-M3-restricted memory T cells are generated, and are indistinguishable from classically restricted T cells in terms of cell surface memory markers and longevity. Early responses of H2-M3- and H2-Kd-restricted memory T cells to reinfection are similar, with increases in size and expression of activation markers. Interestingly, priming of H2-M3-restricted T cells with an L. monocytogenes -derived N-formyl peptide plus anti-CD40 generates memory T cells that expand upon re-exposure to Ag during L. monocytogenes infection. Our data indicate that disparate H2-M3- and MHC class Ia-restricted memory T cell responses reflect intrinsic differences between these T cell populations. Although distinct proliferative programs appear to be hardwired in these populations during primary L. monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag. |
| Keywords: | controlled study; nonhuman; cell proliferation; t lymphocyte; biological markers; animal cell; mouse; animals; mice; cell survival; cell division; animal experiment; animal model; cell population; mice, inbred balb c; mice, inbred c57bl; mice, transgenic; antigen presentation; lymphocyte activation; bacterial protein; cell surface marker; peptide fragments; t-lymphocytes, cytotoxic; histocompatibility antigens class i; t-lymphocyte subsets; memory cell; major histocompatibility complex; immunologic memory; listeriosis; listeria monocytogenes; listeria infections; major histocompatibility antigen class 1; immunization; immunization, secondary; cell surface; antigens, bacterial; heat-shock proteins; bacterial toxins; hemolysin proteins; cd40 ligand monoclonal antibody; reinfection; h-2 antigens; female; priority journal; article; formylpeptide |
| Journal Title: | Journal of Immunology |
| Volume: | 170 |
| Issue: | 4 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2003-02-15 |
| Start Page: | 1862 |
| End Page: | 1869 |
| Language: | English |
| PUBMED: | 12574352 |
| PROVIDER: | scopus |
| DOI: | 10.4049/jimmunol.170.4.1862 |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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