Overexpression of IL-15 in vivo increases antigen-driven memory CD8(+) T cells following a microbe exposure Journal Article
| Authors: | Yajima, T.; Nishimura, H.; Ishimitsu, R.; Watase, T.; Busch, D. H.; Pamer, E. G.; Kuwano, H.; Yoshikai, Y. |
| Article Title: | Overexpression of IL-15 in vivo increases antigen-driven memory CD8(+) T cells following a microbe exposure |
| Abstract: | To elucidate potential roles of IL-15 in the maintenance of memory CD8(+) T cells, we followed the fate of Ag-specific CD8(+) T cells directly visualized with MHC class I tetramers coupled with listeriolysin O (LLO)(91-99) in IL-15 transgenic (Tg) mice after Listeria monocytogenes infection. The numbers of LLO91-99-positive memory CD8(+) T cells were significantly higher at 3 and 6 wk after infection than those in non-Tg mice. The LLO91-99-positive CD8(+) T cells produced IFN-gamma in response to LLO91-99, and an adoptive transfer of CD8(+) T cells from IL-15 Tg mice infected with L monocytogenes conferred a higher level of resistance against L. monocytogenes in normal mice. The CD44(+)CD8(+) T cells from infected IL-15 Tg mice expressed the higher level of Bcl-2. Transferred CD44(+)CD8(+) T cells divided more vigorously in naive IL-15 Tg mice than in non-Tg mice. These results suggest that IL-15 plays an important role in long-term maintenance of Ag-specific memory CD8(+) T cells following microbial exposure via promotion of cell survival and homeostatic proliferation. |
| Keywords: | receptor; proliferation; homeostasis; interleukin 15; transgenic mice; messenger-rna; listeria-monocytogenes; bacterial-infection; beta-chain; natural-killer |
| Journal Title: | Journal of Immunology |
| Volume: | 168 |
| Issue: | 3 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2002-02-01 |
| Start Page: | 1198 |
| End Page: | 1203 |
| Language: | English |
| ACCESSION: | WOS:000173429300029 |
| PROVIDER: | wos |
| PUBMED: | 11801655 |
| DOI: | 10.4049/jimmunol.168.3.1198 |
| Notes: | Article -- Source: Wos |
