Priming of memory but not effector CD8 T cells by a killed bacterial vaccine Journal Article
| Authors: | Lauvau, G.; Vijh, S.; Kong, P.; Horng, T.; Kerksiek, K.; Serbina, N.; Tuma, R. A.; Pamer, E. G. |
| Article Title: | Priming of memory but not effector CD8 T cells by a killed bacterial vaccine |
| Abstract: | Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity. |
| Keywords: | nonhuman; t lymphocyte; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell division; bacteria (microorganisms); time factors; animalia; lymphocyte activation; cellular immunity; cd4-positive t-lymphocytes; substrate specificity; vaccination; effector cell; cytotoxicity, immunologic; memory cell; biochemistry; bacterial vaccines; protozoa; t lymphocyte subpopulation; immunologic memory; listeriosis; listeria monocytogenes; listeria infections; vaccines; live vaccine; immunization; inactivated vaccine; cells; bacteria; bacterial vaccine; vaccines, attenuated; priority journal; article; listeriosis monocytogenes; killed bacterial vaccine |
| Journal Title: | Science |
| Volume: | 294 |
| Issue: | 5547 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2001-11-23 |
| Start Page: | 1735 |
| End Page: | 1739 |
| Language: | English |
| DOI: | 10.1126/science.1064571 |
| PUBMED: | 11721060 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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