Priming of memory but not effector CD8 T cells by a killed bacterial vaccine Journal Article


Authors: Lauvau, G.; Vijh, S.; Kong, P.; Horng, T.; Kerksiek, K.; Serbina, N.; Tuma, R. A.; Pamer, E. G.
Article Title: Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
Abstract: Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.
Keywords: nonhuman; t lymphocyte; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell division; bacteria (microorganisms); time factors; animalia; lymphocyte activation; cellular immunity; cd4-positive t-lymphocytes; substrate specificity; vaccination; effector cell; cytotoxicity, immunologic; memory cell; biochemistry; bacterial vaccines; protozoa; t lymphocyte subpopulation; immunologic memory; listeriosis; listeria monocytogenes; listeria infections; vaccines; live vaccine; immunization; inactivated vaccine; cells; bacteria; bacterial vaccine; vaccines, attenuated; priority journal; article; listeriosis monocytogenes; killed bacterial vaccine
Journal Title: Science
Volume: 294
Issue: 5547
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2001-11-23
Start Page: 1735
End Page: 1739
Language: English
DOI: 10.1126/science.1064571
PUBMED: 11721060
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Gregoire Lauvau
    3 Lauvau
  2. Roman Tuma
    5 Tuma
  3. Eric Pamer
    249 Pamer
  4. Natalya Serbina
    17 Serbina