Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection Journal Article
| Authors: | Min-Oo, G.; Bezman, N. A.; Madera, S.; Sun, J. C.; Lanier, L. L. |
| Article Title: | Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection |
| Abstract: | Apoptosis is critical for the elimination of activated lymphocytes after viral infection. Proapoptotic factor Bim (Bcl2l11) controls T lymphocyte contraction and the formation of memory T cells after infection. Natural killer (NK) cells also undergo antigen-driven expansion to become long-lived memory cells after mouse cytomegalovirus (MCMV) infection; therefore, we examined the role of Bim in regulating the MCMV-driven memory NK cell pool. Despite responding similarly early after infection, Bcl2l11-/- Ly49H+ NK cells show impaired contraction and significantly outnumber wild-type (WT) cells after the expansion phase. The inability to reduce the effector pool leads to a larger Bcl2l11-/- NK memory subset, which displays a less mature phenotype (CD11blo, CD27+) and lower levels of NK cell memoryassociated markers KLRG1 and Ly6C. Bcl2l11-/- memory NK cells demonstrate a reduced response to m157-mediated stimulation and do not protect as effectively as WT memory NK cells in an MCMV challenge model. Thus, Bim-mediated apoptosis drives selective contraction of effector NK cells to generate a pool of mature, MCMV-specific memory cells. © 2014 Min-Oo et al. |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 211 |
| Issue: | 7 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2014-06-30 |
| Start Page: | 1289 |
| End Page: | 1296 |
| Language: | English |
| DOI: | 10.1084/jem.20132459 |
| PROVIDER: | scopus |
| PMCID: | PMC4076589 |
| PUBMED: | 24958849 |
| DOI/URL: | |
| Notes: | Export Date: 1 August 2014 -- CODEN: JEMEA -- Source: Scopus |
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