IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy Journal Article


Authors: Hatzivassiliou, G.; Miller, I.; Takizawa, J.; Palanisamy, N.; Rao, P. H.; Iida, S.; Tagawa, S.; Taniwaki, M.; Russo, J.; Neri, A.; Cattoretti, G.; Clynes, R.; Mendelsohn, C.; Chaganti, R. S. K.; Dalla-Favera, R.
Article Title: IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
Abstract: Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin Cα domain to produce a chimeric IRTA1/Cα fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.
Keywords: controlled study; protein expression; human cell; exons; multiple myeloma; gene expression profiling; cell maturation; introns; tumor cells, cultured; b lymphocyte; b-lymphocytes; chimera; molecular cloning; cloning, molecular; b cell lymphoma; gene expression regulation, neoplastic; lymphoma, b-cell; amino acid sequence; molecular sequence data; rna, messenger; oncogene proteins, fusion; chromosome breakage; chromosome translocation; base sequence; translocation, genetic; protein structure, tertiary; chromosomes, human, pair 1; chromosome 1q; germ-line mutation; multigene family; immunoglobulins; cell surface receptor; receptors, cell surface; immunoglobulin receptor; receptors, fc; myeloma proteins; chromosomes, human, pair 14; immunoglobulin fc fragment; humans; human; priority journal; article; immunoblast
Journal Title: Immunity
Volume: 14
Issue: 3
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2001-03-01
Start Page: 277
End Page: 289
Language: English
DOI: 10.1016/s1074-7613(01)00109-1
PUBMED: 11290337
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Pulivarth H Rao
    55 Rao
  2. Raju S K Chaganti
    276 Chaganti