Cloning and characterization of TNKL, a member of tankyrase gene family Journal Article
| Authors: | Kuimov, A. N.; Kuprash, D. V.; Petrov, V. N.; Vdovichenko, K. K.; Scanlan, M. J.; Jongeneel, C. V.; Lagarkova, Ma; Nedospasov, S. A. |
| Article Title: | Cloning and characterization of TNKL, a member of tankyrase gene family |
| Abstract: | By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis. |
| Keywords: | genetics; molecular genetics; animal; animals; molecular cloning; cloning, molecular; chemistry; amino acid sequence; molecular sequence data; sequence homology, amino acid; nucleotide sequence; base sequence; antibodies; dna primers; primer dna; sequence homology; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; complementary dna; dna, complementary; poly(adp-ribose) polymerases; tankyrase; serex; ankyrin; telomeres; humans; human; article; tankyrases; tnks protein, human |
| Journal Title: | Genes and Immunity |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 1466-4879 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2001-02-01 |
| Start Page: | 52 |
| End Page: | 55 |
| Language: | English |
| PUBMED: | 11294570 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
