The antibacterial arm of the Drosophila innate immune response requires an IκB kinase Journal Article

   

Authors:	Lu, Y.; Wu, L. P.; Anderson, K. V.
Article Title:	The antibacterial arm of the Drosophila innate immune response requires an IκB kinase
Abstract:	The ird5 gene was identified in a genetic screen for Drosophila immune response mutants. Mutations in ird5 prevent induction of six antibacterial peptide genes in response to infection but do not affect the induction of an antifungal peptide gene. Consistent with this finding, Escherichia coli survive 100 times better in ird5 adults than in wild-type animals. The ird5 gene encodes a Drosophila homolog of mammalian IκB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-κB family member.
Keywords:	unclassified drug; gene mutation; gene sequence; sequence analysis; nonhuman; phenotype; mammalia; animals; gene product; drosophila; immunoglobulin enhancer binding protein; animalia; transcription factors; gene expression regulation, developmental; anti-bacterial agents; immune response; protein-serine-threonine kinases; escherichia coli; innate immunity; drosophila melanogaster; gene induction; saccharomyces cerevisiae proteins; drosophila proteins; phosphotransferase; larva; antifungal activity; beta-galactosidase; fungal proteins; antibacterial activity; genes, insect; nf-κb; crosses, genetic; i kappa b; animals, genetically modified; i-kappa b kinase; antimicrobial peptide; relish; relish protein; male; female; priority journal; article; iκb kinase; ird5 protein
Journal Title:	Genes and Development
Volume:	15
Issue:	1
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Date Published:	2001-01-01
Start Page:	104
End Page:	110
Language:	English
DOI:	10.1101/gad.856901
PUBMED:	11156609
PROVIDER:	scopus
PMCID:	PMC312606
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0035187882&partnerID=40&md5=6bf999e540d4087adaa673db607c881d
Notes:	Export Date: 21 May 2015 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/73648