Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila Journal Article
| Authors: | Choe, K. M.; Werner, T.; Stöven, S.; Hultmark, D.; Anderson, K. V. |
| Article Title: | Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila |
| Abstract: | Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-κB family transcription factor Relish. |
| Keywords: | signal transduction; controlled study; unclassified drug; mutation; exons; nonhuman; phenotype; mammalia; animals; gene; genes; signaling; protein; transcription factor; drosophila; immunoglobulin enhancer binding protein; bacteria (microorganisms); animalia; transcription factors; gene expression regulation; immunology; immune response; transcription regulation; molecular recognition; escherichia coli; carrier proteins; alternative splicing; active transport, cell nucleus; cell nucleus; drosophila proteins; expressed sequence tags; protein isoforms; rna, double-stranded; hexapoda; genes, insect; bacteria; infection resistance; lipopolysaccharides; immunity, natural; gram negative bacterium; peptidoglycan; peptidoglycan recognition protein; insect protein; bacterium lipopolysaccharide; negibacteria; antimicrobial cationic peptides; insecta; priority journal; article; arachnida; peptidoglycan recognition proteins (pgrp); transcription factor relish; bacterial cell wall; insect proteins |
| Journal Title: | Science |
| Volume: | 296 |
| Issue: | 5566 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2002-04-26 |
| Start Page: | 359 |
| End Page: | 362 |
| Language: | English |
| DOI: | 10.1126/science.1070216 |
| PUBMED: | 11872802 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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