Cooperative control of Drosophila immune responses by the JNK and NF-κB signaling pathways Journal Article
| Authors: | Delaney, J. R.; Stöven, S.; Uvell, H.; Anderson, K. V.; Engström, Y.; Mlodzik, M. |
| Article Title: | Cooperative control of Drosophila immune responses by the JNK and NF-κB signaling pathways |
| Abstract: | Jun N-terminal kinase (JNK) signaling is a highly conserved pathway that controls both cytoskeletal remodeling and transcriptional regulation in response to a wide variety of signals. Despite the importance of JNK in the mammalian immune response, and various suggestions of its importance in Drosophila immunity, the actual contribution of JNK signaling in the Drosophila immune response has been unclear. Drosophila TAK1 has been implicated in the NF-κB/Relish-mediated activation of antimicrobial peptide genes. However, we demonstrate that Relish activation is intact in dTAK1 mutant animals, and that the immune response in these mutant animals was rescued by overexpression of a downstream JNKK. The expression of a JNK inhibitor and induction of JNK loss-of-function clones in immune responsive tissue revealed a general requirement for JNK signaling in the expression of antimicrobial peptides. Our data indicate that dTAK1 is not required for Relish activation, but instead is required in JNK signaling for antimicrobial peptide gene expression. © 2006 European Molecular Biology Organization | All Rights Reserved. |
| Keywords: | signal transduction; protein expression; mutation; nonhuman; mutant protein; protein function; mammalia; animals; animal tissue; gene expression; stress activated protein kinase; embryo; drosophila; immunoglobulin enhancer binding protein; genetic transcription; enzyme activation; animalia; transcription factors; molecular cloning; immune response; transcription regulation; nf-kappa b; innate immunity; drosophila melanogaster; immunity; immune response gene; cytoskeleton; drosophila proteins; larva; phosphoprotein phosphatase; nf-κb; transforming growth factor beta activated kinase 1; map kinase kinase 4; immunity, natural; jnk; relish; polypeptide antibiotic agent; stress activated protein kinase inhibitor; antimicrobial cationic peptides |
| Journal Title: | EMBO Journal |
| Volume: | 25 |
| Issue: | 13 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-07-12 |
| Start Page: | 3068 |
| End Page: | 3077 |
| Language: | English |
| DOI: | 10.1038/sj.emboj.7601182 |
| PUBMED: | 16763552 |
| PROVIDER: | scopus |
| PMCID: | PMC1500970 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 43" - "Export Date: 4 June 2012" - "CODEN: EMJOD" - "Source: Scopus" |
