Cutting edge: Stage-specific requirement of IL-18 for antiviral NK cell expansion Journal Article
| Authors: | Madera, S.; Sun, J. C. |
| Article Title: | Cutting edge: Stage-specific requirement of IL-18 for antiviral NK cell expansion |
| Abstract: | Although NK cells are considered part of the innate immune system, recent studies have demonstrated the ability of Ag-experienced NK cells to become long-lived and contribute to potent recall responses similar to T and B cells. The precise signals that promote the generation of a long-lived NK cell response are largely undefined. In this article, we demonstrate that NK cells require IL-18 signaling to generate a robust primary response during mouse CMV (MCMV) infection but do not require this signal for memory cell maintenance or recall responses. IL-12 signaling and STAT4 in activated NK cells increased the expression of the adaptor protein MyD88, which mediates signaling downstream of the IL-18 and IL-1 receptors. During MCMV infection, NK cells required MyD88, but not IL-1R, for optimal expansion. Thus, an IL-18-MyD88 signaling axis facilitates the prolific expansion of NK cells in response to primary viral infection, but not recall responses. |
| Keywords: | signal transduction; controlled study; nonhuman; mouse; animal experiment; animal model; cellular immunity; gamma interferon; natural killer cell; cytokine production; cytomegalovirus infection; cell expansion; t lymphocyte activation; myeloid differentiation factor 88; interleukin 12; interleukin 18; interleukin 1 receptor; stat4 protein; article |
| Journal Title: | Journal of Immunology |
| Volume: | 194 |
| Issue: | 4 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2015-02-15 |
| Start Page: | 1408 |
| End Page: | 1412 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1402001 |
| PROVIDER: | scopus |
| PMCID: | PMC4323636 |
| PUBMED: | 25589075 |
| DOI/URL: | |
| Notes: | Export Date: 2 March 2015 -- Source: Scopus |
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