Divergent role for STAT5 in the adaptive responses of natural killer cells Journal Article
| Authors: | Wiedemann, G. M.; Grassmann, S.; Lau, C. M.; Rapp, M.; Villarino, A. V.; Friedrich, C.; Gasteiger, G.; O'Shea, J. J.; Sun, J. C. |
| Article Title: | Divergent role for STAT5 in the adaptive responses of natural killer cells |
| Abstract: | Wiedemann et al. demonstrate that Stat5a and Stat5b are induced by IL-12 and STAT4 signaling in NK cells following MCMV infection. They further provide evidence that the cytokines IL-2 and IL-15 upstream of STAT5 differentially promote the early and late stages of the adaptive NK cell response to MCMV infection. © 2020 The Author(s) Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the roles of this transcription factor and its upstream cytokines interleukin-2 (IL-2) and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. We demonstrate that STAT5 is induced in NK cells by IL-12 and STAT4 early after infection and that partial STAT5 deficiency results in a defective capacity of NK cells to generate long-lived memory cells. Furthermore, we find a functional dichotomy of IL-2 and IL-15 signaling outputs during viral infection, whereby both cytokines drive clonal expansion, but only IL-15 is required for memory NK cell survival. We thus highlight a role for STAT5 signaling in promoting an optimal anti-viral NK cell response. © 2020 The Author(s) |
| Keywords: | memory; il-2; clonal expansion; il-15; stat5; nk cell; mcmv |
| Journal Title: | Cell Reports |
| Volume: | 33 |
| Issue: | 11 |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press |
| Date Published: | 2020-12-15 |
| Start Page: | 108498 |
| Language: | English |
| DOI: | 10.1016/j.celrep.2020.108498 |
| PROVIDER: | scopus |
| PMCID: | PMC7773031 |
| PUBMED: | 33326784 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 January 2021 -- Source: Scopus |
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