Molecular programming of immunological memory in natural killer cells Journal Article
| Authors: | Beaulieu, A. M.; Madera, S.; Sun, J. C. |
| Article Title: | Molecular programming of immunological memory in natural killer cells |
| Abstract: | Immunological memory is a hallmark of the adaptive immune system. Although natural killer (NK) cells have traditionally been classified as a component of the innate immune system, they have recently been shown in mice and humans to exhibit certain features of immunological memory, including an ability to undergo a clonal-like expansion during virus infection, generate long-lived progeny (i.e. memory cells), and mediate recall responses against previously encountered pathogens—all characteristics previously ascribed only to adaptive immune responses by B and T cells in mammals. To date, the molecular events that govern the generation of NK cell memory are not completely understood. Using a mouse model of cytomegalovirus infection, we demonstrate that individual pro-inflammatory IL-12, IL-18, and type I-IFN signaling pathways are indispensible and play non-redundant roles in the generation of virus-specific NK cell memory. Furthermore, we discovered that antigen- specific proliferation and protection by NK cells is mediated by the transcription factor Zbtb32, which is induced by pro-inflammatory cytokines and promotes a cell cycle program in activated NK cells. A greater understanding of the molecular mechanisms controlling NK cell responses will provide novel strategies for tailoring vaccines to target infectious disease. © 2015, Springer International Publishing Switzerland. |
| Keywords: | signal transduction; unclassified drug; interferon; nonhuman; protein function; lymphocyte proliferation; molecular dynamics; transcription factor; lymphocyte activation; antigen specificity; clonal variation; natural killer cell; cytokine production; target cell; innate immunity; molecular biology; adaptive immunity; memory cell; protein determination; cytomegalovirus infection; cell expansion; interleukin 12; innate immune system; interleukin 18; immunological memory; microrna 155; adaptive immune system; human; priority journal; article; cytokine stimulation; nk cell memory; transcription factor zbtb32; molecular programming |
| Journal Title: | Advances in Experimental Medicine and Biology |
| Volume: | 850 |
| ISSN: | 0065-2598 |
| Publisher: | Springer |
| Date Published: | 2015-09-01 |
| Start Page: | 81 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1007/978-3-319-15774-0_7 |
| PROVIDER: | scopus |
| PUBMED: | 26324348 |
| DOI/URL: | |
| Notes: | Chapter 7 in "Crossroads Between Innate and Adaptive Immunity V" (ISBN: 978-3-319-15773-3) -- Export Date: 2 October 2015 -- Source: Scopus |
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