Molecular therapies for colorectal cancer metastatic to the liver Journal Article
| Authors: | Mayer-Kuckuk, P.; Banerjee, D.; Kemeny, N.; Fong, Y.; Bertino, J. R. |
| Article Title: | Molecular therapies for colorectal cancer metastatic to the liver |
| Abstract: | Colorectal cancers are the fourth most commonly diagnosed cancers and will account for over 56,000 deaths in the United States in 2002. A majority of patients with advanced colorectal cancer develop liver metastases during the course of their disease. Treatment of colorectal cancer metastatic to the liver by surgery or chemotherapy is limited and most patients succumb to their disease. Therefore, a broad spectrum of novel treatments, including innovative molecular therapies such as gene and immunotherapy or replication-competent viral therapy, is under preclinical investigation and several clinical trials are in progress. Here we review molecular therapies for colorectal cancer metastatic to the liver. |
| Keywords: | vasculotropin; controlled study; unclassified drug; clinical trial; disease course; drug tolerability; review; angiogenesis inhibitor; fluorouracil; drug safety; nonhuman; antineoplastic agents; liver neoplasms; united states; antineoplastic agent; colorectal cancer; mouse; animals; gene targeting; interleukin 2; cancer immunotherapy; dendritic cell; carcinoembryonic antigen; granulocyte macrophage colony stimulating factor; luciferase; animal experiment; animal model; dexamethasone; antineoplastic activity; drug effect; protein p53; cancer mortality; viral gene delivery system; animalia; genetic vectors; fever; colorectal neoplasms; liver metastasis; liver; immunotherapy; folinic acid; rat; matrix metalloproteinase; gene therapy; beta galactosidase; simplexvirus; drug infusion; mitomycin c; thymidine kinase; beta 2 microglobulin; adenovirus vector; virus replication; metastases; disease models, animal; thymidylate synthase inhibitor; floxuridine; herpes simplex virus 1; ganciclovir; interleukin 12; clinical trials; tissue plasminogen activator; adenoviridae; onyx 015; newcastle disease virus; newcastle disease paramyxovirus; cytosine deaminase; flucytosine; endostatin; edrecolomab; human herpesvirus 1; paramyxoviridae; hla b27 antigen; humans; human; molecular therapies; replication-competent viral therapy; allovectin 7; alvac cea b7.1; sch 58500; tg 1021 |
| Journal Title: | Molecular Therapy |
| Volume: | 5 |
| Issue: | 5 |
| ISSN: | 1525-0016 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-05-01 |
| Start Page: | 492 |
| End Page: | 500 |
| Language: | English |
| DOI: | 10.1006/mthe.2002.0596 |
| PUBMED: | 11991739 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
136Banerjee -
363Bertino -
775Fong -
18
Mayer-Kuckuk -
543Kemeny
Related MSK Work