Randomized clinical trials in breast cancer Journal Article
| Authors: | Klauber-DeMore, N.; Boolbol, S. K.; Derossis, A. M.; Ruo, L.; Bernik, S. F.; Borgen, P. I. |
| Article Title: | Randomized clinical trials in breast cancer |
| Abstract: | Before the second half of this century, treatment approaches to breast cancer were radical and disfiguring. In the past four decades, however, multiple prospective randomized trials have made highly significant advances in the management of patients with this disease. These trials have established, in select patients, breast conservation therapy as a primary therapeutic procedure, and radiation therapy as a means to improve local control and survival. This article provides an overview of some of these trials. |
| Keywords: | cancer survival; controlled study; surgical technique; major clinical study; clinical trial; histopathology; review; fluorouracil; placebo; patient selection; cancer radiotherapy; cancer staging; prospective studies; evidence-based medicine; controlled clinical trial; breast cancer; randomized controlled trial; cyclophosphamide; deep vein thrombosis; breast neoplasms; lung embolism; randomized controlled trials; stroke; medical oncology; tamoxifen; cancer control; estrogen receptor; breast surgery; meta analysis; meta-analysis; humans; human; female |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-01-01 |
| Start Page: | 53 |
| End Page: | 88 |
| Language: | English |
| DOI: | 10.1016/s1055-3207(03)00075-9 |
| PUBMED: | 11928802 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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