Selection of appropriate biomarkers to monitor effectiveness of ovarian function suppression in pre-menopausal patients with ER+ breast cancer Review

   

Authors:	McCann, K. E.; Goldfarb, S. B.; Traina, T. A.; Regan, M. M.; Vidula, N.; Kaklamani, V.
Review Title:	Selection of appropriate biomarkers to monitor effectiveness of ovarian function suppression in pre-menopausal patients with ER+ breast cancer
Abstract:	Use of gonadotropin-releasing hormone (GnRH) agonists has been widely adopted to provide reversible ovarian function suppression for pre-menopausal breast cancer patients who are also receiving aromatase inhibitor or tamoxifen therapy based on results of 25 randomized trials representing almost 15,000 women demonstrating a survival benefit with this approach. Past clinical trials designed to establish the efficacy of GnRH agonists have monitored testosterone in the prostate cancer setting and estradiol in the breast cancer setting. We explore the merits of various biomarkers including estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) and their utility for informing GnRH agonist treatment decisions in breast cancer. Estradiol remains our biomarker of choice in ensuring adequate ovarian function suppression with GnRH agonist therapy among pre-menopausal women with breast cancer. We recommend future trials to continue to focus on estradiol levels as the primary endpoint, as they have in the past. © 2024, The Author(s).
Keywords:	cancer patient; biological marker; aromatase inhibitor; estrogen; prostate cancer; goserelin; leuprorelin; body mass; tamoxifen; gonadorelin agonist; mass fragmentography; estradiol; testosterone; adipose tissue; follitropin; luteinizing hormone; early menopause; ovary function; estrogen receptor positive breast cancer; human; article
Journal Title:	npj Breast Cancer
Volume:	10
ISSN:	2374-4677
Publisher:	Nature Publishing Group
Date Published:	2024-01-19
Start Page:	8
Language:	English
DOI:	10.1038/s41523-024-00614-w
PROVIDER:	scopus
PMCID:	PMC10798954
PUBMED:	38242892
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182712596&doi=10.1038%2fs41523-024-00614-w&partnerID=40&md5=21eff697fea1baf22c7c528223559166
Notes:	Article -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/213191