Intraoperative radiation therapy for breast cancer: Technical notes Journal Article
| Authors: | Veronesi, U.; Gatti, G.; Luini, A.; Intra, M.; Orecchia, R.; Borgen, P.; Zelefsky, M.; McCormick, B.; Sacchini, V. |
| Article Title: | Intraoperative radiation therapy for breast cancer: Technical notes |
| Abstract: | Interest in intraoperative radiation therapy (IORT) for breast cancer is increasing as the possible benefits of this technique for the patient become apparent. The rationale for the use of this segmental radiation therapy in place of whole-breast irradiation is based on the finding that approximately 85% of breast relapses are confined to the same quadrant of the breast as the primary tumor. Phase I and II trials have demonstrated no increase in postsurgical complication rates following the use of single-dose IORT in localized breast cancers. Longer follow-up is needed to assess the cosmetic outcome. Clinical trials to evaluate the effectiveness of IORT in the treatment of breast cancer are currently under way at the European Institute of Oncology (EIO) at the University of Milan, Italy, and at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York. Here we report the two different techniques in use in these trials. |
| Keywords: | treatment outcome; surgical technique; clinical trial; cancer localization; cancer recurrence; united states; adjuvant therapy; cancer radiotherapy; radiation dose; radiotherapy, adjuvant; follow up; methodology; phase 2 clinical trial; breast cancer; radiotherapy dosage; pathology; breast neoplasms; radiation response; dose-response relationship, radiation; postoperative complication; instrumentation; intraoperative period; breast tumor; intermethod comparison; phase 1 clinical trial; radiotherapy, high-energy; linear accelerator; iridium 192; segmental mastectomy; mastectomy, segmental; electron beam; italy; clinical trials, phase ii; megavoltage radiotherapy; clinical trials, phase i; intraoperative radiation therapy; humans; human; female; article |
| Journal Title: | Breast Journal |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 1075-122X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2003-03-01 |
| Start Page: | 106 |
| End Page: | 112 |
| Language: | English |
| DOI: | 10.1046/j.1524-4741.2003.09208.x |
| PUBMED: | 12603383 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work