Randomized clinical trials in breast cancer Journal Article
| Authors: | Crago, A. M.; Azu, M.; Tierney, S.; Morrow, M. |
| Article Title: | Randomized clinical trials in breast cancer |
| Abstract: | Breast cancer remains the most common cancer diagnosed in women and the second leading cause of cancer-related deaths in this group. Significant advances in the treatment of breast cancer and in the ability to screen for the disease mean that it is also one of the most curable forms of cancer. Long-term updates of the trials reviewed in the previous edition of this article have demonstrated that breast-conserving therapy remains a viable option for most patients, and that local control is related to overall survival. New chemotherapeutic options and endocrine therapies are available to select subsets of patients, and the use of endocrine therapy in breast cancer prevention has been shown to be of clear benefit. The sheer number of breast cancer-related randomized, controlled trials makes it impossible to review all level Ia evidence in this article but, where possible, extensive referencing and tabular review of related trials are used to provide the reader with a clear outline of the central data dictating current standard of care. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; surgical technique; clinical trial; review; cancer recurrence; doxorubicin; fluorouracil; placebo; paclitaxel; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; postoperative care; methotrexate; follow up; lymph node metastasis; lymph node dissection; endometrium cancer; prospective study; sentinel lymph node biopsy; evidence based medicine; cancer prevention; controlled clinical trial; breast cancer; mastectomy; randomized controlled trial; aromatase inhibitor; randomized controlled trials as topic; cyclophosphamide; breast neoplasms; cancer mortality; high risk patient; exemestane; cancer hormone therapy; cancer invasion; partial mastectomy; tamoxifen; epirubicin; letrozole; taxane derivative; trastuzumab; anastrozole; anthracycline; literature review; intraductal carcinoma; venous thromboembolism; raloxifene; breast-conserving therapy; randomized clinical trials |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 33 |
| End Page: | 58 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.003 |
| PUBMED: | 19914559 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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