Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo Journal Article
| Authors: | Trcka, J.; Moroi, Y.; Clynes, R. A.; Goldberg, S. M.; Bergtold, A.; Perales, M. A.; Ma, M.; Ferrone, C. R.; Carroll, M. C.; Ravetch, J. V.; Houghton, A. N. |
| Article Title: | Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo |
| Abstract: | Complement and Fc receptor (FcR)-positive cells mediate effector functions of antibodies. Antibody-dependent immunity against the melanosome membrane glycoprotein gp75/tyrosinase-related protein-1 (TYRP-1) of melanocytes leads to autoimmune hypopigmentation (vitiligo) in mice. Hypopigmentation occurred in mice deficient in activating FcR containing the common γ subunit (FcγR γ-/-) and in mice deficient in the C3 complement component. Mice doubly deficient in both FcγR γ and C3 did not develop hypopigmentation, suggesting that complement and FcγR formed redundant mechanisms. Following passive immunization with antibody, no further adaptive immune responses were required. Chimeric FcγR γ-/-,C3-/- mice reconstituted with bone marrow from either FcγR γ-/- or C3-/- mice or adoptively transferred with FcγR γ+/- macrophages did develop antibody-mediated hypopigmentation. Thus, either complement or macrophages expressing activating FcγR can independently and alternatively mediate disease in a model of autoimmune vitiligo. |
| Keywords: | controlled study; protein expression; nonhuman; mouse; animals; mice; mice, knockout; bone marrow; melanocytes; animal model; genotype; mice, inbred c57bl; chimera; immune response; recombinant fusion proteins; membrane glycoproteins; adoptive transfer; fc receptor; macrophage; macrophages; autoimmune disease; tyrosinase related protein 1; oxidoreductases; antibody; complement; hypopigmentation; vitiligo; passive immunization; immunization, passive; receptors, fc; complement c3; complement activation; priority journal; article |
| Journal Title: | Immunity |
| Volume: | 16 |
| Issue: | 6 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2002-06-01 |
| Start Page: | 861 |
| End Page: | 868 |
| Language: | English |
| DOI: | 10.1016/s1074-7613(02)00327-8 |
| PUBMED: | 12121667 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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