Fc receptors are required in passive and active immunity to melanoma Journal Article
| Authors: | Clynes, R.; Takechi, Y.; Moroi, Y.; Houghton, A.; Ravetch, J. V. |
| Article Title: | Fc receptors are required in passive and active immunity to melanoma |
| Abstract: | Effective tumor immunity requires recognition of tumor cells coupled with the activation of host effector responses. Fc receptor (FcR) γ(-/-) mice, which lack the activating FcγR types I and III, did not demonstrate protective tumor immunity in models of passive and active immunization against a relevant tumor differentiation antigen, the brown locus protein gp75. In wild-type mice, passive immunization with mAb against gp75 or active immunization against gp75 prevented the development of lung metastases. This protective response was completely abolished in FcRγ-deficient mice. Immune responses were intact in γ(-/-) mice because IgG titers against gp75 develop normally in γ(-/-) mice immunized with gp75. However, uncoupling of the FcγR effector pathway from antibody recognition of tumor antigens resulted in a loss of protection against tumor challenge. These data demonstrate an unexpected and critical role for FcRs in mediating tumor cytotoxicity in vivo and suggest that enhancement of FcγR-mediated antibody-dependent cellular cytotoxicity by inflammatory cells is a key step in the development of effective tumor immunotherapeutics. |
| Keywords: | controlled study; nonhuman; proteins; animal cell; mouse; animals; mice; bcg vaccine; melanoma; tumor differentiation; animal experiment; animal model; tumor antigen; mice, inbred c57bl; animalia; monoclonal antibody; lung metastasis; antibodies, monoclonal; antigens, neoplasm; membrane glycoproteins; vaccination; melanoma, experimental; tumor immunity; fc receptor; effector cell; immunity; immunoglobulin g2a; tumor rejection; oxidoreductases; glycoprotein; antibody titer; antibody dependent cellular cytotoxicity; active immunization; idiotypic antibody; freund adjuvant; passive immunization; intraperitoneal drug administration; immunization, passive; receptors, fc; peritoneum macrophage; subcutaneous drug administration; female; priority journal; article |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 95 |
| Issue: | 2 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1998-01-20 |
| Start Page: | 652 |
| End Page: | 656 |
| Language: | English |
| DOI: | 10.1073/pnas.95.2.652 |
| PUBMED: | 9435247 |
| PROVIDER: | scopus |
| PMCID: | PMC18475 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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