Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice Journal Article
| Authors: | Sylvestre, D.; Clynes, R.; Ma, M.; Warren, H.; Carroll, M. C.; Ravetch, J. V. |
| Article Title: | Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice |
| Abstract: | The role of complement in immunoglobulin G-triggered inflammation was studied in mice genetically deficient in complement components C3 and C4. Using the reverse passive Arthus reaction and experimental models of immune hemolytic anemia and immune thrombocytopenia, we show that these mice bare types II and III inflammatory responses that are indistinguishable from those of wild type animals. Complement-deficient and wild-type animals exhibit comparable levels of erythrophagocytosis and platelet clearance in response to cytotoxic anti-red blood cell and antiplatelet antibodies. Furthermore, in the reverse passive Arthus reaction, soluble immune complexes induce equivalent levels of hemmorhage, edema, and neutrophillic infiltration in complement-deficient and wild-type animals. In contrast, mice that are genetically deficient in the expression of Fc receptors exhibit grossly diminished reactions by both cytotoxic antibodies and soluble immune complexes. These studies provide strong evidence that the activation of cell- based FcγR receptors, but not complement, are required for antibody- triggered murine inflammatory responses. |
| Keywords: | controlled study; nonhuman; mouse; animals; mice; mice, knockout; animal tissue; edema; bleeding; thrombocytopenia; animal experiment; animal model; inflammation; neutrophil; immunoglobulin g; fc receptor; neutrophils; autoimmune hemolytic anemia; phagocytosis; erythrocytes; complement component c4; complement; erythrophagocytosis; blood platelets; rabbits; antigen antibody complex; complement component c3; complement c3; priority journal; article; anemia, hemolytic; cytotoxic antibody; complement deficiency; complement c4; erythrocyte antibody; thrombocyte antibody |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 184 |
| Issue: | 6 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 1996-12-01 |
| Start Page: | 2385 |
| End Page: | 2392 |
| Language: | English |
| DOI: | 10.1084/jem.184.6.2385 |
| PUBMED: | 8976192 |
| PROVIDER: | scopus |
| PMCID: | PMC2196366 |
| DOI/URL: | |
| Notes: | Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work