Cladribine underdosing in hairy-cell leukemia: A cause for apparent response failure Journal Article
| Authors: | Golde, D. W.; Jakubowiak, A.; Caggiano, J ; Heaney, M. L. |
| Article Title: | Cladribine underdosing in hairy-cell leukemia: A cause for apparent response failure |
| Abstract: | While chemotherapy overdose is often readily discovered, underdosing errors are seldom appreciated. We report two patients with hairy-cell leukemia who apparently failed to respond to cladribine administered by continuous portable pump infusion. It was determined that both patients received one-seventh of the prescribed dose, although the orders were written correctly. The errors resulted in the administration of 1 day's dose over 1 week. The use of 7-day portable pump infusion therapy for cladribine can be associated with misdosing, and is an occult cause of apparent failure to respond in hairy-cell leukemia. |
| Keywords: | adult; middle aged; treatment failure; prednisone; case report; dose response; flow cytometry; erythropoietin; cyclophosphamide; continuous infusion; prescription; instrumentation; bone marrow biopsy; drug infusion; azathioprine; granulocyte colony stimulating factor; dose calculation; infusion; infusions, parenteral; error; cladribine; hairy cell leukemia; infusion pump; medication errors; medication error; hairy-cell leukemia; hydroxychloroquine sulfate; leukemia, hairy cell; humans; human; male; priority journal; article; response failure; underdosing |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 43 |
| Issue: | 2 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2002-01-01 |
| Start Page: | 365 |
| End Page: | 367 |
| Language: | English |
| DOI: | 10.1080/10428190290006170 |
| PUBMED: | 11999571 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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