Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium Journal Article

   


Authors: Felix, A. S.; Gaudet, M. M.; La Vecchia, C.; Nagle, C. M.; Shu, X. O.; Weiderpass, E.; Adami, H. O.; Beresford, S.; Bernstein, L.; Chen, C.; Cook, L. S.; De Vivo, I.; Doherty, J. A.; Friedenreich, C. M.; Gapstur, S. M.; Hill, D.; Horn-Ross, P. L.; Lacey, J. V.; Levi, F.; Liang, X.; Lu, L.; Magliocco, A.; McCann, S. E.; Negri, E.; Olson, S. H.; Palmer, J. R.; Patel, A. V.; Petruzella, S.; Prescott, J.; Risch, H. A.; Rosenberg, L.; Sherman, M. E.; Spurdle, A. B.; Webb, P. M.; Wise, L. A.; Xiang, Y. B.; Xu, W.; Yang, H. P.; Yu, H.; Zeleniuch-Jacquotte, A.; Brinton, L. A.
Article Title: Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium
Abstract: Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR=0.81, 95% CI=0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR=0.69, 95% CI=0.58-0.82), older age at first use (≥35 years pooled-OR=0.53, 95% CI=0.43-0.67), older age at last use (≥45 years pooled-OR=0.60, 95% CI=0.50-0.72), longer duration of use (≥10 years pooled-OR=0.61, 95% CI=0.52-0.71) and recent use (within 1 year of study entry pooled-OR=0.39, 95% CI=0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.
Keywords: adult; controlled study; cancer risk; treatment duration; cancer staging; endometrium cancer; disease association; prevalence; smoking; age; body mass; diabetes mellitus; hormonal therapy; risk reduction; postmenopause; etiology; pooled analysis; parity; contraception; human; female; article; endometrial neoplasm; copper intrauterine device; hormone releasing intrauterine device; intrauterine contraceptive device; oral contraceptive use
Journal Title: International Journal of Cancer
Volume: 136
Issue: 5
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 2015-03-01
Start Page: E410
End Page: E422
Language: English
DOI: 10.1002/ijc.29229
PROVIDER: scopus
PMCID: PMC4267918
PUBMED: 25242594
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84918828502&partnerID=40&md5=e0081c0a788f14ad669fc28b12cc0ffa
Notes: Export Date: 2 January 2015 -- Source: Scopus
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MSK Authors
  1. Sara H Olson
    234 Olson
  2. Xiaolin Liang
    62 Liang
  3. Stacey Lee Petruzella
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