Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium Journal Article

   


Authors: Jordan, S. J.; Na, R.; Weiderpass, E.; Adami, H. O.; Anderson, K. E.; van den Brandt, P. A.; Brinton, L. A.; Chen, C.; Cook, L. S.; Doherty, J. A.; Du, M.; Friedenreich, C. M.; Gierach, G. L.; Goodman, M. T.; Krogh, V.; Levi, F.; Lu, L.; Miller, A. B.; McCann, S. E.; Moysich, K. B.; Negri, E.; Olson, S. H.; Petruzella, S.; Palmer, J. R.; Parazzini, F.; Pike, M. C.; Prizment, A. E.; Rebbeck, T. R.; Reynolds, P.; Ricceri, F.; Risch, H. A.; Rohan, T. E.; Sacerdote, C.; Schouten, L. J.; Serraino, D.; Setiawan, V. W.; Shu, X. O.; Sponholtz, T. R.; Spurdle, A. B.; Stolzenberg-Solomon, R. Z.; Trabert, B.; Wentzensen, N.; Wilkens, L. R.; Wise, L. A.; Yu, H.; La Vecchia, C.; De Vivo, I.; Xu, W.; Zeleniuch-Jacquotte, A.; Webb, P. M.
Article Title: Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium
Abstract: A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 control women. We used one- and two-stage meta-analytic approaches to estimate pooled odds ratios (ORs) for the association between exposures and endometrial cancer risk. Ever having a full-term pregnancy was associated with a 41% reduction in risk of endometrial cancer compared to never having a full-term pregnancy (OR = 0.59, 95% confidence interval [CI] 0.56-0.63). The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further ~15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. Incomplete pregnancy was also associated with decreased endometrial cancer risk (7%-9% reduction per pregnancy). Twin births appeared to have the same effect as singleton pregnancies. Our pooled analysis shows that, while the magnitude of the risk reduction is greater for a full-term pregnancy than an incomplete pregnancy, each additional pregnancy is associated with further reduction in endometrial cancer risk, independent of age at last full-term pregnancy. These results suggest that the very high progesterone level in the last trimester of pregnancy is not the sole explanation for the protective effect of pregnancy. © 2020 UICC
Keywords: adult; controlled study; aged; major clinical study; case control study; cancer risk; endometrial cancer; endometrium cancer; cohort analysis; aging; observational study; risk reduction; pregnancy outcome; progesterone; spontaneous abortion; parity; gestation period; progesterone blood level; twins; childbirth; third trimester pregnancy; human; female; priority journal; article; induced abortion; miscarriage; sex of offspring
Journal Title: International Journal of Cancer
Volume: 148
Issue: 9
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 2021-05-01
Start Page: 2068
End Page: 2078
Language: English
DOI: 10.1002/ijc.33360
PUBMED: 33105052
PROVIDER: scopus
PMCID: PMC7969437
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096684730&doi=10.1002%2fijc.33360&partnerID=40&md5=996f0f4580862229a74a89c0182ece2f
Notes: Article -- Export Date: 1 April 2021 -- Source: Scopus
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  1. Malcolm Pike
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  2. Sara H Olson
    234 Olson
  3. Stacey Lee Petruzella
    26 Petruzella
  4. Mengmeng Du
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