Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers Journal Article


Authors: Kotsopoulos, J.; Lubinski, J.; Lynch, H. T.; Klijn, J.; Ghadirian, P.; Neuhausen, S. L.; Kim-Sing, C.; Foulkes, W. D.; Möller, P.; Isaacs, C.; Domchek, S.; Randall, S.; Offit, K.; Tung, N.; Ainsworth, P.; Gershoni-Baruch, R.; Eisen, A.; Daly, M.; Karlan, B.; Saal, H. M.; Couch, F.; Pasini, B.; Wagner, T.; Friedman, E.; Rennert, G.; Eng, C.; Weitzel, J.; Sun, P.; Narod, S. A.; Garber, J.; Gilchrist, D.; Osborne, M.; Fishman, D.; Warner, E.; McLennan, J.; McKinnon, W.; Merajver, S.; Olsson, H.; Provencher, D.; Pasche, B.; Evans, G.; Meschino, W. S.; Lemire, E.; Chudley, A.; Rayson, D.; Bellati, C.
Article Title: Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Abstract: An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case-control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98-1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective. © 2007 Springer Science+Business Media, LLC.
Keywords: adolescent; adult; controlled study; middle aged; gene mutation; major clinical study; mutation; case-control studies; cancer risk; genetic predisposition to disease; breast cancer; odds ratio; risk factors; breast neoplasms; brca1 protein; brca2 protein; heterozygote; time factors; questionnaire; oncogene; registries; genes, brca1; genes, brca2; pregnancy; age distribution; brca1; pregnancy complications, neoplastic; brca2; genetic counseling; parity; case-control study; age at first birth
Journal Title: Breast Cancer Research and Treatment
Volume: 105
Issue: 2
ISSN: 0167-6806
Publisher: Springer  
Date Published: 2007-10-01
Start Page: 221
End Page: 228
Language: English
DOI: 10.1007/s10549-006-9441-3
PUBMED: 17245541
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: BCTRD" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Kenneth Offit
    523 Offit