Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: Results from the WECARE study Journal Article


Authors: Poynter, J. N.; Langholz, B.; Largent, J.; Mellemkjær, L.; Bernstein, L.; Malone, K. E.; Lynch, C. F.; Borg, A.; Concannon, P.; Teraoka, S. N.; Xue, S.; Diep, A. T.; Törngren, T.; Begg, C. B.; Capanu, M.; Haile, R. W.; Bernstein, J. L.
Article Title: Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: Results from the WECARE study
Abstract: Objective Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. Methods The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and CBC for mutation carriers and non-carriers. Results None of the associations between reproductive factors and CBC risk differed between mutation carriers and non-carriers. The increase in risk with younger age at menarche and decrease in risk in women with more than two full-term pregnancies seen in non-carriers were not significantly different in carriers (adjusted RRs = 1.31, 95% CI 0.65-2.65 and 0.53, 95% CI 0.19-1.51, respectively). No significant associations between the other reproductive factors and CBC risk were observed in mutation carriers or non-carriers. Conclusion For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers. © Springer Science+Business Media B.V. 2010.
Keywords: adult; controlled study; gene mutation; major clinical study; mutation; case-control studies; cancer risk; antineoplastic agent; neoplasms; breast cancer; logistic models; risk factors; breast neoplasms; brca1 protein; brca2 protein; risk factor; menarche; risk; cancer hormone therapy; genes, brca2; pregnancy; high risk population; genetic risk; menopause; brca1; brca2; population based case control study; reproduction; contralateral breast cancer; reproductive factors; parity; reproductive history
Journal Title: Cancer Causes & Control
Volume: 21
Issue: 6
ISSN: 0957-5243
Publisher: Springer  
Date Published: 2010-06-01
Start Page: 839
End Page: 846
Language: English
DOI: 10.1007/s10552-010-9510-0
PUBMED: 20130978
PROVIDER: scopus
PMCID: PMC2873079
DOI/URL:
Notes: --- - "Export Date: 20 April 2011" - "CODEN: CCCNE" - "Source: Scopus"
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MSK Authors
  1. Colin B Begg
    240 Begg
  2. Marinela Capanu
    211 Capanu
  3. Jonine L Bernstein
    104 Bernstein