Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: The WECARE Study Journal Article


Authors: Figueiredo, J. C.; Haile, R. W.; Bernstein, L.; Malone, K. E.; Largent, J.; Langholz, B.; Lynch, C. F.; Bertelsen, L.; Capanu, M.; Concannon, P.; Borg, A.; Børresen-Dale, A. L.; Diep, A.; Teraoka, S.; Törngren, T.; Xue, S.; Bernstein, J. L.
Article Title: Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: The WECARE Study
Abstract: The potential effects of oral contraceptive (OC) and postmenopausal hormone (PMH) use are not well understood among BRCA1 or BRCA2 (BRCA1/2) deleterious mutation carriers with a history of breast cancer. We investigated the association between OC and PMH use and risk of contralateral breast cancer (CBC) in the WECARE (Women's Environment, Cancer, and Radiation Epidemiology) Study. The WECARE Study is a population-based case-control study of 705 women with asynchronous CBC and 1,398 women with unilateral breast cancer, including 181 BRCA1/2 mutation carriers. Risk-factor information was assessed by telephone interview. Mutation status was measured using denaturing high-performance liquid chromatography followed by direct sequencing in all participants. Outcomes, treatment, and tumor characteristics were abstracted from medical records. Ever use of OCs was not associated with risk among noncarriers (RR = 0.87; 95% CI = 0.66-1.15) or BRCA2 carriers (RR = 0.82; 95% CI = 0.21-3.13). BRCA1 carriers who used OCs had a nonsignificant greater risk than nonusers (RR = 2.38; 95% CI = 0.72-7.83). Total duration of OC use and at least 5 years of use before age 30 were associated with a nonsignificant increased risk among mutation carriers but not among noncarriers. Few women had ever used PMH and we found no significant associations between lifetime use and CBC risk among carriers and noncarriers. In conclusion, the association between OC/PMH use and risk of CBC does not differ significantly between carriers and noncarriers; however, because carriers have a higher baseline risk of second primaries, even a potential small increase in risk as a result of OC use may be clinically relevant. © 2009 Springer Science+Business Media, LLC.
Keywords: adult; controlled study; middle aged; young adult; gene mutation; gene sequence; major clinical study; mutation; case-control studies; cancer risk; genetic predisposition to disease; breast cancer; risk factors; breast neoplasms; brca1 protein; brca2 protein; heterozygote; medical record review; risk factor; estrogen replacement therapy; genes, brca1; genes, brca2; interview; high performance liquid chromatography; chromatography, high pressure liquid; neoplasms, second primary; postmenopause; brca1; brca2; oral contraceptive agent; oral contraception; hormone substitution; population based case control study; contralateral; asynchronous bilateral; oral contraceptives; postmenopausal hormones; contraceptives, oral
Journal Title: Breast Cancer Research and Treatment
Volume: 120
Issue: 1
ISSN: 0167-6806
Publisher: Springer  
Date Published: 2010-02-01
Start Page: 175
End Page: 183
Language: English
DOI: 10.1007/s10549-009-0455-5
PUBMED: 19597986
PROVIDER: scopus
PMCID: PMC2835545
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "CODEN: BCTRD" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Marinela Capanu
    221 Capanu
  2. Jonine L Bernstein
    105 Bernstein