Breastfeeding and endometrial cancer risk: An analysis from the epidemiology of endometrial cancer consortium Journal Article

   


Authors: Jordan, S. J.; Na, R.; Johnatty, S. E.; Wise, L. A.; Adami, H. O.; Brinton, L. A.; Chen, C.; Cook, L. S.; Dal Maso, L.; De Vivo, I.; Freudenheim, J. L.; Friedenreich, C. M.; La Vecchia, C.; McCann, S. E.; Moysich, K. B.; Lu, L.; Olson, S. H.; Palmer, J. R.; Petruzella, S.; Pike, M. C.; Rebbeck, T. R.; Ricceri, F.; Risch, H. A.; Sacerdote, C.; Setiawan, V. W.; Sponholtz, T. R.; Shu, X. O.; Spurdle, A. B.; Weiderpass, E.; Wentzensen, N.; Yang, H. P.; Yu, H.; Webb, P. M.
Article Title: Breastfeeding and endometrial cancer risk: An analysis from the epidemiology of endometrial cancer consortium
Abstract: OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with individual-level data from three cohort and 14 case-control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I 2 and Q statistics and metaregression. RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81-0.98). Longer average duration of breastfeeding per child was associated with lower risk of endometrial cancer, although there appeared to be some leveling of this effect beyond 6-9 months. The association with ever breastfeeding was not explained by greater parity and did not vary notably by body mass index or histologic subtype (grouped as endometrioid and mucinous compared with serous and clear cell). CONCLUSION: Our findings suggest that reducing endometrial cancer risk can be added to the list of maternal benefits associated with breastfeeding. Ongoing promotion, support, and facilitation of this safe and beneficial behavior might therefore contribute to the prevention of this increasingly common cancer.
Keywords: population; fertility; lactation; metaanalysis; replacement therapy
Journal Title: Obstetrics and Gynecology
Volume: 129
Issue: 6
ISSN: 0029-7844
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-06-01
Start Page: 1059
End Page: 1067
Language: English
ACCESSION: WOS:000402714100020
DOI: 10.1097/aog.0000000000002057
PROVIDER: wos
PUBMED: 28486362
PMCID: PMC5473170
Notes: Article -- Source: Wos
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MSK Authors
  1. Malcolm Pike
    190 Pike
  2. Sara H Olson
    234 Olson
  3. Stacey Lee Petruzella
    26 Petruzella
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