Age at last birth in relation to risk of endometrial cancer: Pooled analysis in the epidemiology of endometrial cancer consortium Journal Article
| Authors: | Setiawan, V. W.; Pike, M. C.; Karageorgi, S.; Deming, S. L.; Anderson, K.; Bernstein, L.; Brinton, L. A.; Cai, H.; Cerhan, J. R.; Cozen, W.; Chen, C.; Doherty, J.; Freudenheim, J. L.; Goodman, M. T.; Hankinson, S. E.; Lacey, J. V.; Liang, X.; Lissowska, J.; Lu, L.; Lurie, G.; Mack, T.; Matsuno, R. K.; McCann, S.; Moysich, K. B.; Olson, S. H.; Rastogi, R.; Rebbeck, T. R.; Risch, H.; Robien, K.; Schairer, C.; Shu, X. O.; Spurdle, A. B.; Strom, B. L.; Thompson, P. J.; Ursin, G.; Webb, P. M.; Weiss, N. S.; Wentzensen, N.; Xiang, Y. B.; Yang, H. P.; Yu, H.; Horn-Ross, P. L.; De Vivo, I. |
| Article Title: | Age at last birth in relation to risk of endometrial cancer: Pooled analysis in the epidemiology of endometrial cancer consortium |
| Abstract: | Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (Ptrend < 0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95 confidence interval: 0.85, 0.90). Women who last gave birth at 40 years of age or older had a 44 decreased risk compared with women who had their last birth under the age of 25 years (95 confidence interval: 47, 66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years. © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. |
| Keywords: | adult; controlled study; major clinical study; case-control studies; cancer risk; united states; endometrial neoplasms; endometrium cancer; disease association; cohort studies; cohort analysis; odds ratio; risk factors; risk factor; risk; confidence interval; body mass; australia; pregnancy; tumor; epidemiology; health risk; poland; china; parity; reproductive history; birth rate; maternal age; childbirth; age structure; childbearing |
| Journal Title: | American Journal of Epidemiology |
| Volume: | 176 |
| Issue: | 4 |
| ISSN: | 0002-9262 |
| Publisher: | Oxford University Press |
| Date Published: | 2012-08-15 |
| Start Page: | 269 |
| End Page: | 278 |
| Language: | English |
| DOI: | 10.1093/aje/kws129 |
| PUBMED: | 22831825 |
| PROVIDER: | scopus |
| PMCID: | PMC3491967 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 28 January 2013" - "CODEN: AJEPA" - "Source: Scopus" |
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