Predictive value of endocervical curettage at cervical conization and provider practices in management of high-grade cervical dysplasia Journal Article


Authors: Barlin, J. N.; Bristow, R. E.; Murillo, A. M.; Zahurak, M.; Veras, E.; Salani, R.
Article Title: Predictive value of endocervical curettage at cervical conization and provider practices in management of high-grade cervical dysplasia
Abstract: OBJECTIVE: To determine the utility of endocervical curettage (ECC) at cervical conization for predicting residual or recurrent dysplasia and to evaluate differences in management between general gynecologists and gynecologic oncologists. STUDY DESIGN: From February 1999 to November 2007, 192 patients with high-grade dysplasia on conization were retrospectively identified. Data were analyzed for 54 patients who underwent repeat conization or hysterectomy to evaluate predictors of disease. Data for all patients were analyzed based on provider. RESULTS: Among patients who underwent secondary procedures, 68.5% (37/54) had residual or recurrent disease. Eighty-six percent of patients with a positive ECC had residual or recurrent disease compared to 48% of patients with a negative ECC (OR 6.91, CI 1.595-30.00, p = 0.01). Among all patients, 77% (148/192) were managed by a generalist, and 23% (44/192) by a gynecologic oncologist. Oncologists were significantly more likely to perform a hysterectomy (45.5% vs. 14.2%, OR 5.04, CI 2.38-10.69, p<0.0001). CONCLUSION: Endocervical curettage at the time of conization with high-grade dysplasia is a simple and reliable predictor of residual recurrent disease and should be performed routinely. Gynecologic oncologists are more likely than general gynecologists to perform a hysterectomy in the management of high-grade dysplasia on conization. (J Reprod Med 2010;55:129-133)
Keywords: risk; residual disease; intraepithelial neoplasia; cervical neoplasia; conization; endocervical curettage; papanicolaou; smear; subsequent hysterectomy; persistence
Journal Title: Journal of Reproductive Medicine
Volume: 55
Issue: 3-4
ISSN: 0024-7758
Publisher: Sci Printers & Publ Inc  
Date Published: 2010-03-01
Start Page: 129
End Page: 133
Language: English
ACCESSION: ISI:000277600300008
PROVIDER: wos
PUBMED: 20506673
Notes: --- - Proceedings Paper - "Source: Wos"
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