Clinicopathologic features of early adenocarcinoma of the cervix initially managed with cervical conization Journal Article
| Authors: | Poynor, E. A.; Marshall, D.; Sonoda, Y.; Slomovitz, B. M.; Barakat, R. R.; Soslow, R. A. |
| Article Title: | Clinicopathologic features of early adenocarcinoma of the cervix initially managed with cervical conization |
| Abstract: | Objective.: To evaluate the clinicopathologic features of microinvasive adenocarcinoma of the cervix in order to guide the management of patients with this disease. Materials and methods.: A retrospective review was conducted of patients diagnosed with early invasive, ≤ 5 mm stromal invasion, adenocarcinoma of the cervix by a cervical conization between 1992 and 1999 at our institution. Information was abstracted on tumor histopathologic type, grade, and depth of invasion as well as presence or absence of disease at the margins of conization, lymphovascular spread, and the presence of disease in subsequent pathology specimens including the parametrium and pelvic lymph nodes (PLNs). Results.: Thirty-three patients were identified. The mean age of the patients in the study population was 41.6 years (range, 29-53 years). Fifteen women were age 35 years or younger. Six patients had invasion ≤ 1 mm, 9 patients had invasion > 1 mm and ≤ 2 mm, 6 patients had invasion > 2 mm and ≤ 3 mm, 6 patients had invasion > 3 mm and ≤ 4 mm, and 6 patients had invasion > 4 mm and ≤ 5 mm. Three patients were treated with a conization only, 4 patients were treated with a simple hysterectomy, 25 patients were treated with a radical hysterectomy (RH) and PLN dissection (PLND), and 1 patient was treated with a radical trachelectomy and PLND. Ten patients had positive conization margins for invasive cancer, 3 patients had margins positive for adenocarcinoma in situ, 14 patients had negative margins, and in 6 patients the margin status could not be evaluated. Of the 10 patients with positive margins, 5 of 10 (50%) had residual disease in the subsequent surgical specimen. Three patients who underwent definitive management with conization alone originally had positive margins, underwent a second repeat conization, and are included in this group. Of the 16 patients with negative margins, no patient had residual disease in a subsequent surgical specimen. Of the 25 patients who underwent a RH and PLND, none had parametrial involvement and none had PLN involvement. All patients remained without evidence of disease at median follow-up of 30 months. Conclusions.: Historically, the standard management of early invasive adenocarcinoma of the cervix has been controversial, and some clinicians continue to favor radical treatments. Based on the absence of parametrial spread and PLN involvement in early lesions, physicians and patients should consider treatment with conization with negative margins (when future fertility is desired) or simple hysterectomy. Prospective studies are required to document the safety of this approach. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | adult; clinical article; controlled study; middle aged; surgical technique; retrospective studies; clinical feature; histopathology; pathogenesis; disease free survival; follow up; hysterectomy; pelvis lymph node; lymphatic metastasis; pelvis; lymphadenectomy; adenocarcinoma; pathology; retrospective study; outcome assessment (health care); cancer invasion; lymph vessel; patient care; disease severity; medical information; evaluation; carcinoma in situ; reoperation; new york city; neoplasm invasiveness; uterine cervical neoplasms; radical hysterectomy; uterine cervix carcinoma; medical records; uterine cervix conization; conization; early invasive adenocarcinoma of the cervix; microinvasive adenocarcinoma of the cervix; trachea surgery |
| Journal Title: | Gynecologic Oncology |
| Volume: | 103 |
| Issue: | 3 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-12-01 |
| Start Page: | 960 |
| End Page: | 965 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2006.05.041 |
| PUBMED: | 16860853 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 4 June 2012" - "CODEN: GYNOA" - "Source: Scopus" |
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