Predominant autoantibody production by early human B cell precursors Journal Article
| Authors: | Wardemann, H.; Yurasov, S.; Schaefer, A.; Young, J. W.; Meffre, E.; Nussenzweig, M. C. |
| Article Title: | Predominant autoantibody production by early human B cell precursors |
| Abstract: | During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including polyreactive and anti-nuclear specificities. Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies. |
| Keywords: | human cell; gene deletion; gene; genes; cell maturation; prevalence; cell line; cell differentiation; tumor cells, cultured; enzyme linked immunosorbent assay; b-lymphocytes; stem cell; selection (genetics); molecular cloning; immunology; amino acid sequence; immunoglobulin heavy chains; recombination, genetic; antibody specificity; bone marrow cell; antibodies; autoantibody; autoantibodies; antibody; cytosol; antibody production; antibody diversity; complementarity determining regions; b lymphocyte activation; genes, immunoglobulin; humans; human; priority journal; article; antibodies, antinuclear; self reactivity |
| Journal Title: | Science |
| Volume: | 301 |
| Issue: | 5638 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2003-09-05 |
| Start Page: | 1374 |
| End Page: | 1377 |
| Language: | English |
| DOI: | 10.1126/science.1086907 |
| PUBMED: | 12920303 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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