An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells Journal Article
| Authors: | Mayer, C. T.; Nieke, J. P.; Gazumyan, A.; Cipolla, M.; Wang, Q.; Oliveira, T. Y.; Ramos, V.; Monette, S.; Li, Q. Z.; Gershwin, M. E.; Kashkar, H.; Nussenzweig, M. C. |
| Article Title: | An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells |
| Abstract: | B lymphocytes acquire self-reactivity as an unavoidable byproduct of antibody gene diversification in the bone marrow and in germinal centers (GCs). Autoreactive B cells emerging from the bone marrow are silenced in a series of well-defined checkpoints, but less is known about how self-reactivity that develops by somatic mutation in GCs is controlled. Here, we report the existence of an apoptosis-dependent tolerance checkpoint in post-GC B cells. Whereas defective GC B cell apoptosis has no measurable effect on autoantibody development, disruption of post-GC apoptosis results in accumulation of autoreactive memory B cells and plasma cells, antinuclear antibody production, and autoimmunity. The data presented shed light on mechanisms that regulate immune tolerance and the development of autoantibodies. |
| Keywords: | apoptosis; autoantibody; b lymphocytes; antinuclear antibodies |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 117 |
| Issue: | 40 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2020-10-06 |
| Start Page: | 24957 |
| End Page: | 24963 |
| Language: | English |
| DOI: | 10.1073/pnas.2015372117 |
| PUBMED: | 32963096 |
| PROVIDER: | scopus |
| PMCID: | PMC7547173 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2020 -- Source: Scopus |
