Persistent expression of autoantibodies in SLE patients in remission Journal Article


Authors: Yurasov, S.; Tiller, T.; Tsuiji, M.; Velinzon, K.; Pascual, V.; Wardemann, H.; Nussenzweig, M. C.
Article Title: Persistent expression of autoantibodies in SLE patients in remission
Abstract: A majority of the antibodies expressed by nascent B cells in healthy humans are self-reactive, but most of these antibodies are removed from the repertoire during B cell development. In contrast, untreated systemic lupus erythematosus (SLE) patients fail to remove many of the self-reactive and polyreactive antibodies from the naive repertoire. Here, we report that SLE patients in clinical remission continue to produce elevated numbers of self-reactive and polyreactive antibodies in the mature naive B cell compartment, but the number of B cells expressing these antibodies is lower than in patients with active disease. Our finding that abnormal levels of self-reactive mature naive B cells persist in the majority of patients in clinical remission suggests that early checkpoint abnormalities are an integral feature of SLE. JEM © The Rockefeller University Press.
Keywords: adolescent; child; clinical article; controlled study; protein expression; cell compartmentalization; immunoglobulin; b lymphocyte; b-lymphocytes; reverse transcriptase polymerase chain reaction; remission; systemic lupus erythematosus; enzyme-linked immunosorbent assay; autoantibody; autoantibodies; cell lysate; fluorescent antibody technique, indirect; lupus erythematosus, systemic; genes, immunoglobulin
Journal Title: Journal of Experimental Medicine
Volume: 203
Issue: 10
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2006-10-02
Start Page: 2255
End Page: 2261
Language: English
DOI: 10.1084/jem.20061446
PUBMED: 16966430
PROVIDER: scopus
PMCID: PMC2118096
DOI/URL:
Notes: --- - "Cited By (since 1996): 40" - "Export Date: 4 June 2012" - "CODEN: JEMEA" - "Source: Scopus"
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  1. Sergey Yurasov
    13 Yurasov