Persistent expression of autoantibodies in SLE patients in remission Journal Article
| Authors: | Yurasov, S.; Tiller, T.; Tsuiji, M.; Velinzon, K.; Pascual, V.; Wardemann, H.; Nussenzweig, M. C. |
| Article Title: | Persistent expression of autoantibodies in SLE patients in remission |
| Abstract: | A majority of the antibodies expressed by nascent B cells in healthy humans are self-reactive, but most of these antibodies are removed from the repertoire during B cell development. In contrast, untreated systemic lupus erythematosus (SLE) patients fail to remove many of the self-reactive and polyreactive antibodies from the naive repertoire. Here, we report that SLE patients in clinical remission continue to produce elevated numbers of self-reactive and polyreactive antibodies in the mature naive B cell compartment, but the number of B cells expressing these antibodies is lower than in patients with active disease. Our finding that abnormal levels of self-reactive mature naive B cells persist in the majority of patients in clinical remission suggests that early checkpoint abnormalities are an integral feature of SLE. JEM © The Rockefeller University Press. |
| Keywords: | adolescent; child; clinical article; controlled study; protein expression; cell compartmentalization; immunoglobulin; b lymphocyte; b-lymphocytes; reverse transcriptase polymerase chain reaction; remission; systemic lupus erythematosus; enzyme-linked immunosorbent assay; autoantibody; autoantibodies; cell lysate; fluorescent antibody technique, indirect; lupus erythematosus, systemic; genes, immunoglobulin |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 203 |
| Issue: | 10 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2006-10-02 |
| Start Page: | 2255 |
| End Page: | 2261 |
| Language: | English |
| DOI: | 10.1084/jem.20061446 |
| PUBMED: | 16966430 |
| PROVIDER: | scopus |
| PMCID: | PMC2118096 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 40" - "Export Date: 4 June 2012" - "CODEN: JEMEA" - "Source: Scopus" |
